Objective:To investigate the clinical effect of interventional therapy for congenital heart disease(CHD).Methods: 100 patients with CHD were randomly divided into two groups,respectively adopt the traditional thoracotomy therapy and interventional therapy,the clinical data were comparatively analyzed.Results:48 of 50 patients had successful traditional thoracotomy surgery,perioperative complications occurred in 2 patients;48 of 50 patients had successful interventional therapy,perioperative complications occurred in 2 patients.Conclusion:interventional therapy for congenital heart disease has high safety,less trauma,quicker recovery,simple operation,no operation scar,less complications and other advantages,it is worthy of clinical application.