Objective: for the treatment of risperidone elderly mental disorders of observation and analysis on the efficacy and safety. Methods: the clinical study mainly in our hospital in May 2009 to May 2013 treated 100 cases of elderly patients with mental disorder as the research object. Based on the principle of random distribution, al patients were divided into control group and experimental group, 50 cases each group. Control the main implement perphenazine therapy, the main implementation of risperidone treatment. On two groups of patients with clinical efficacy and safety were observed and compared. Results: clinical research results show that the experimental group patients clinical total effective rate and the control group, there is no statistical y significant difference, P > 0.05; The experimental group the incidence of adverse reactions of patients is lower than the control group, the difference is statistical y significant,P<0.05). Conclusion: the clinical research results show that using risperidone treatment of elderly mental disorders, has good curative effect, safety and good, worthy of promotion and popularization.