Multiple factors influencing clinical pregnancy rate of intrauterine insemination
Objective:To explore the correlation between multiple factors and clinical pregnancy rate of intrauterine insemination(AID-IUI),and to seek a method to further improve the central pregnancy rate.Methods:A total of 440 cycles of AID-IUI were performed in 257 couples from 2014 to December 2022 in our center.The women were divided into three groups according to their age:＜30,30～35,＞35;according to their body mass index(BMI):＜18.5,18.5～24,24～28,≥28;The patients were divided into natural cycle group and ovulation promoting cycle group,and the total number of sperm with forward motion after treatment(PTMS)were divided into(10～30)× 106,(30～40)× 106,≥40 × 106 groups According to the incubation time after semen treatment,the rats were divided into three groups:0～10 min,10～40 min,≥40 min;Single factor and multi-factor regression analysis were carried out for each factor.Results:The clinical pregnancy rates of the women aged＜30,30～35 and＞35 were 33.62％,27.11％and 26.19％respectively(P＞0.05).The clinical pregnancy rate was 33.7％in the unobstructed group and 29.6％in the unobstructed group(P＞0.05).The clinical pregnancy rate(32.16％)in the ovula-tion-promoting group was higher than that(27.39％)in the natural group(P＞0.05).Body mass index(BMI):＜18.5,18.5～24,24～28 and ≥28 were 35.48％,31.27％,30.26％and 15.38％respectively(P＞0.05).There was no signifi-cant difference in clinical pregnancy rate among PTMS groups(P＞0.05).The pregnancy rate was 33.82％in the group of 10～40 min after semen treatment,higher than 23.53％in the group of 0～10 min and 28.57％in the group of ≥40 min(P＞0.05).Logistic regression analysis showed that BMI was an important factor influencing clinical pregnancy rate in AID-IUI.Conclusion:It is suggested that the BMI of women treated with AID-IUI should be controlled within 28 to improve the clinical pregnancy rate;A good success rate could be achieved with a PTMS of more than 10 × 106,regardless of whether the sperm was inseminated once or twice;The pregnancy outcome of artificial insemination is affected by the incubation time after sperm optimal treatment to some extent.The operation within 10～40 minutes after sperm optimal treatment is advocated to improve pregnancy rate.
Artificial insemination with donor spermClinical pregnancy rateIntrauterine inseminationLogistic regression a-nalysis
万方数据
维普
