Efficacy,safety and symptoms of LNG-IUS and dydrogesterone in the treatment of perimenopausal AUB
Objective:To investigate the efficacy,safety and symptoms of LNG-IUS(levonorgestrel intrauterine sustained re-lease system)and dydrogestrel in the treatment of perimenopausal AUB(abnormal uterine bleeding).Methods:A total of 81 patients with perimenopausal AUB admitted to our hospital from July 2018 to October 2020 were selected and divided into two groups according to random number table method.The control group(n=40)was treated with dydrogesterone,and the obser-vation group(n=41)was treated with LNG-IUS,and the treatment effects of the two groups were compared.Results:The total effective rate of observation group(100.0%)was significantly higher than control group(82.5%)(P＜0.05).After treatment,compared with the control group,the observation group had lower PBAC(menstrual blood loss diagram)score,shorter period,less menstrual volume,smaller endometrial thickness,higher hemoglobin(Hb),red blood cell count(RBC)and hematocrit(P＜0.05);Compared with the control group,the serum hormone level in observation group was lower(P＜0.05);There is no significant difference in the incidence of adverse reactions between the two groups(P＜0.05).Conclusion:Compared with dydrogesterone,LNG-IUS is more effective and safe in the treatment of perimenopausal AUB,and can effec-tively improve symptoms and regulate hormone secretion.
DydrogesteronePerimenopauseLevonorgestrel intrauterine sustained release system
万方数据
维普
