Effect of ultra-short-acting multiple subcutaneous insulin injections on islet beta cell function and blood glucose control in patients with type 2 diabetes
Objective:To investigate the effects of ultra-short-acting multiple subcutaneous insulin injections on islet beta cell function and blood glucose control in patients with type 2 diabetes mellitus(T2DM).Methods:60 T2DM patients admitted to the outpatient department from June 2022 to December 2023 were selected as the study subjects,all of whom were given ultra-short-action multiple subcutaneous insulin injections,and the function of islet beta cells and blood glucose control before and af-ter treatment were observed.At the same time,60 T2DM patients were divided into low HbA1c group(32 cases)and high HbA1c group(28 cases)according to HbA1c level,and the difference of islet β cell function and blood glucose before and after treatment was compared between the two groups.Results:After treatment,islet β cell function index[HOMA-β(C-P)In]and fasting C-peptide(FC-P)were significantly increased compared with before treatment(P＜0.05),insulin resistance index[HOMA-IR(C-P)In]and fasting blood glucose(FBG)were significantly decreased compared with before treatment(P＜0.05).The difference of HOMA-β(C-P)In、HOMA-IR(C-P)In and FBG before and after treatment in low HbA1c group was higher than that in high HbA1c group(P＜0.05),but the difference of FC-P between the two groups was not statistically sig-nificant(P＞0.05).Conclusion:Ultra-short-acting multiple subcutaneous insulin injection can improve islet beta cells and ef-fectively control blood glucose in T2DM patients,and blood glucose and insulin beta cell function are relatively better in pa-tients with low HbA1c before and after treatment.
Type 2 diabetes mellitusUltra-short-acting multiple subcutaneous insulin injectionsIslet beta cell functionBlood glucose control
万方数据
维普
