超短效多次胰岛素皮下注射对2型糖尿病患者胰岛β细胞功能和血糖控制的影响

Effect of ultra-short-acting multiple subcutaneous insulin injections on islet beta cell function and blood glucose control in patients with type 2 diabetes

綦才辉 ¹李宁¹

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作者信息

1. 东营市人民医院,山东东营 257091
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摘要

目的:探讨超短效多次胰岛素皮下注射对2型糖尿病(T2DM)患者胰岛β细胞功能和血糖控制的影响.方法:研究对象选取2022年6月至2023年12月门诊收治的60例T2DM患者为研究对象,均给予超短效多次胰岛素皮下注射治疗,观察治疗前后胰岛β细胞功能、血糖控制情况.同时,将60例T2DM患者按糖化血红蛋白(HbA1c)水平分为低HbA1c组32例和高HbA1c组28例,比较两组治疗前后胰岛β细胞功能、血糖变化差值.结果:治疗后,胰岛β细胞功能指数[HOMA-β(C-P)In]、空腹C肽(FC-P)相对于治疗前明显提升(P＜0.05),胰岛素抵抗指数[HOMA-IR(C-P)In]、空腹血糖(FBG)相对于治疗前均明显降低(P＜0.05);低HbA1c组患者治疗前后HOMA-β(C-P)In差值、HOMA-IR(C-P)In差值、FBG差值高于高HbA1c组(P＜0.05),但两组FC-P差值无统计学意义(P＞0.05).结论:超短效多次胰岛素皮下注射治疗可改善T2DM患者胰岛β细胞,有效控制血糖,且低HbA1c患者治疗前后血糖、胰岛素β细胞功能改善相对更佳.

Abstract

Objective:To investigate the effects of ultra-short-acting multiple subcutaneous insulin injections on islet beta cell function and blood glucose control in patients with type 2 diabetes mellitus(T2DM).Methods:60 T2DM patients admitted to the outpatient department from June 2022 to December 2023 were selected as the study subjects,all of whom were given ultra-short-action multiple subcutaneous insulin injections,and the function of islet beta cells and blood glucose control before and af-ter treatment were observed.At the same time,60 T2DM patients were divided into low HbA1c group(32 cases)and high HbA1c group(28 cases)according to HbA1c level,and the difference of islet β cell function and blood glucose before and after treatment was compared between the two groups.Results:After treatment,islet β cell function index[HOMA-β(C-P)In]and fasting C-peptide(FC-P)were significantly increased compared with before treatment(P＜0.05),insulin resistance index[HOMA-IR(C-P)In]and fasting blood glucose(FBG)were significantly decreased compared with before treatment(P＜0.05).The difference of HOMA-β(C-P)In、HOMA-IR(C-P)In and FBG before and after treatment in low HbA1c group was higher than that in high HbA1c group(P＜0.05),but the difference of FC-P between the two groups was not statistically sig-nificant(P＞0.05).Conclusion:Ultra-short-acting multiple subcutaneous insulin injection can improve islet beta cells and ef-fectively control blood glucose in T2DM patients,and blood glucose and insulin beta cell function are relatively better in pa-tients with low HbA1c before and after treatment.

关键词

2型糖尿病/超短效多次胰岛素皮下注射/胰岛β细胞功能/血糖控制

Key words

Type 2 diabetes mellitus/Ultra-short-acting multiple subcutaneous insulin injections/Islet beta cell function/Blood glucose control

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出版年

2024

中外女性健康研究

武汉大学

中外女性健康研究

ISSN：2096-0417

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