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抗HER2乳腺癌ADC药物研究进展

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乳腺癌发病率居女性恶性肿瘤首位,其是由于乳腺上皮细胞发生增殖失控,进而恶变。在乳腺癌治疗时,抗人表皮生长因子受体2(HER2)乳腺癌抗体药物耦联物(ADC)的应用逐渐受到重视,本文就对乳腺癌治疗中常用的抗HER2乳腺癌ADC药物(恩美曲妥珠单抗、德曲妥珠单抗、曲妥珠单抗多卡马嗪、维迪西妥单抗、MM-302、XMT-1522、ARX788、MEDI4276)的应用效果进行综述,以期为抗HER2乳腺癌ADC药物的合理应用提供参考。
Research progress of anti-HER2 breast cancer ADC drugs
The incidence of breast cancer ranks first among female malignant tumors,which is due to the uncontrolled prolifer-ation of breast epithelial cells,and then malignant transformation.In the treatment of breast cancer,the application of anti-hu-man epidermal growth factor receptor 2(HER2)breast cancer antibody drug conjugate(ADC)has been paid more and more at-tention,in this paper,the anti-HER2 breast cancer ADC drugs commonly used in the treatment of breast cancer(enmetrastu-zumab,trastuzumab,trastuzumab,trastuzumab dokamazin,vidicetuzumab,MM-302,XMT-1522,ARX788,MEDI4276)were reviewed in order to provide reference for the rational application of anti-HER2 breast cancer ADC drugs.

Breast cancerHuman epidermal growth factor receptor 2Antibody-drug conjugateEnmetrastuzumab

迟曰梅、周涛

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日照市人民医院乳腺甲状腺外科,山东日照 276800

乳腺癌 人表皮生长因子受体2 抗体药物耦联物 恩美曲妥珠单抗

2024

中外女性健康研究
武汉大学

中外女性健康研究

ISSN:2096-0417
年,卷(期):2024.(7)