Analysis of subtype distribution and cervical lesions in 321 female patients with HPV infection
Objective:To analyze the subtype distribution and cervical lesions of 321 female patients infected with human papil-lomavirus(HPV).Methods:321 cases of female patients with HPV infection in our hospital from January 2021 to December 2022 were retrospectively included as the research object,and the clinical data of the patients were counted.All patients with HPV infection completed cervical histopathological examination.The distribution of in 321 patients with HPV infection was statistically analyzed.The results of HPV subtypes and cervical histopathological examination,the age distribution of cervical histopathological examination results,and the results of cervical histopathological examination in patients with high-risk and low-risk HPV infection were analyzed,cervical lesions in women with single and multiple HPV infections.Results:Among the 321 patients with HPV infection,227 cases(70.72%)had single infection and 94 cases(29.28%)had multiple infections.There were 289 cases(90.03%)of high-risk HPV infection and 32 cases(9.97%)of low-risk HPV infection.There were 74 cases(23.05%)without cervical lesions,207 cases(64.49%)with low-grade lesions,37 cases(11.53%)with high-grade le-sions,and 3 cases(0.93%)with cervical cancer.There were 86 cases(26.79%)aged<25 years,154 cases(47.98%)aged 25～34 years,81 cases(25.23%)aged 35～44 years.In patients without cervical lesions,the detection rate of high HPV sub-types were HPV52,HPV51,HPV16;in patients with low-grade lesions,HPV subtypes with higher detection rates were HPV52,HPV16,HPV18,and HPV81;in patients with high-grade lesions,HPV subtypes with higher detection rates were HPV16,HPV52,HPV58,and HPV18;in patients with cervical cancer,the higher detection rate of HPV subtypes were HPV18.The age distribution of patients with cervical lesions was mainly 25～34 years old.Compared with patients of the low-risk HPV group,the proportion of patients with high-grade lesions,and cervical cancer of the high-risk HPV group were high-er,but there was no difference(P>0.05).There was no difference in the proportion of patients with low-grade lesions,high-grade lesions,and cervical cancer in the single group and multiple groups(P>0.05).Conclusion:The distribution of HPV subtypes in female patients with HPV infection was different.The common HPV subtypes in different grades of cervical lesions are HPV52,HPV16,HPV18,etc.,and high-risk HPV patients have a higher risk of high-grade lesions and cervical cancer,and 25～34 years old HPV infected patients have a higher risk of cervical lesions.
Human papillomavirusCervical cell lesionsGenotyping
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