Effect of nifedipine plus magnesium sulfate on urokinogen and cadherin levels in patients with severe gestational hypertension
Objective:To study the effect of nifedipine and magnesium sulfate on the levels of urokinin and urocadherin in pa-tients with severe gestational hypertension.Methods:The study subjects were 120 patients with severe gestational hyperten-sion treated in our hospital from September 2022 to October 2023,divided into control group(n=60,magnesium sulfate)and observation group(n=60,nifedipine in the control group)to compare the blood pressure level,blood pressure duration,urina-ry protein level,vascular endothelial function,incidence of adverse reactions and pregnancy outcome.Results:1)After 1 week of treatment,Lower blood pressure levels in both groups,And the observation group was lower than the control group(P<0.05),The recovery time of blood pressure in the observation group was shorter than that in the control group(P<0.05);2)After 1 week of treatment,In both groups,urinary protein,cadherin and urokininogen levels were decreased in 24h,Moreo-ver,the observation group was lower than the control group(P<0.05);3)After 1 week of treatment,In both groups,And higher in the observation group(P<0.05),Endothelin-1,both have decreased cadherin in vascular endothelial cells,And it was lower in the observation group(P<0.05);4)The incidence of adverse reactions(11.67%VS 13.33%)in the two groups was close to that of patients(P>0.05);(5)After the completion of the follow-up visit,The incidence of adverse pregnancy outcomes(5.00%VS 16.67%)was lower in the observation group(P<0.05).Conclusion:Nifedipine and mag-nesium sulfate can reduce the blood pressure level,promote the recovery of their blood pressure,reduce the urinary protein lev-el,improve the function.
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