The application of Danshen injection combined with methyldopamine in patients with gestational hypertension and its impact on vascular endothelial function and pregnancy outcomes
Objective:To explore the application of Danshen injection combined with methyldopa in patients with gestational hy-pertension(HDP)and its impact on vascular endothelial function and pregnancy outcomes.Methods:94 patients with HDP ad-mitted to our hospital from June 2022 to May 2023 were randomly divided into two groups.A total of 47 patients were included in the control group and treated with methyldopamine;A total of 47 patients were included in the study group and treated with Danshen Injection in combination with the control group.Compare blood pressure values,endothelial function indicators,post-operative adverse reactions,and incidence of adverse pregnancy outcomes between two groups.Results:There was no differ-ence in blood pressure and endothelial function indicators between the two groups before treatment(both P>0.05).Compared with the control group after 14 days of treatment,the study group had lower systolic blood pressure and diastolic function(both P<0.05),lower endothelin-1(ET-1)index(P<0.05),and higher nitric oxide(NO)index(P<0.05).No differ-ence in the incidence of adverse reactions between the both groups(P>0.05).The evaluation results of adverse pregnancy outcomes showed that compared with the control group of 19.15%,the study group had a lower 4.26%(P<0.05).Conclu-sion:Danshen injection combined with methyldopa can reduce blood pressure,improve vascular endothelial function,and en-sure pregnancy outcomes in patients with HDP.
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