首页|转录因子在植物内质网胁迫中的作用及分子机制研究进展

转录因子在植物内质网胁迫中的作用及分子机制研究进展

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植物的一生常遭受各种胁迫,导致错误折叠蛋白或未折叠蛋白在细胞内积累,进而引发内质网胁迫.植物主要通过内质网质量监控系统(ER quality control,ERQC)、内质网相关降解(ER-associated degrada-tion,ERAD)、未折叠蛋白反应(unfolded protein response,UPR)以及自噬来抵抗内质网胁迫.其中UPR是一种通过信号转导来增强蛋白质折叠和修复能力以及促进错误折叠蛋白降解的途径,植物UPR中IRE1和bZIP17/28两种途径已被证实.许多转录因子(transcription factors)参与响应内质网胁迫,主要涉及bZIP、NAC、HSF、WRKY和NF-Y核因子等基因家族,是作物抗逆遗传改良的目标基因,因此研究内质网应激调控机制具有重要意义.本文主要简述了内质网应激中ERQC、ERAD、UPR以及自噬反应的一般原理并对参与内质网应激的转录因子的调控机制研究进展进行综述,以期为植物内质网胁迫中转录因子的作用机制解析及作物抗逆遗传改良提供参考.
Advances in roles and molecular mechanisms of transcription factors in endoplasmic reticulum stress in plants
Plants are often subjected to various stresses throughout their lifespan,which lead to the accu-mulation of misfolded or unfolded proteins in cells,which in turn trigger ER stress.Plants are mainly regu-lated by ER quality control(ERQC),ER-associated degradation(ERAD),unfolded protein response(UPR)and autophagy to resist ER stress.Among them,UPR is a pathway that enhances protein folding and re-pair capacity and promotes the degradation of misfolded proteins through signal transduction.Two path-ways,IRE1 and bZIP17/28,have been identified in plant UPR.Many transcription factors are involved in the response to ER stress,mainly involving bZIP.NAC,HSF,WRKY and NF-Y gene family,which are the target genes for genetic improvement of crop stress resistance.Therefore,it is of great significance to study the regulatory mechanism of ER stress.In this review,we briefly described the general principles of ERQC,ERAD,UPR and autophagy in ER stress,and reviewed the regulatory mechanisms of transcription factors involved in ER stress,in order to provide reference for the understanding of the mechanism of transcrip-tion factors in plant ER stress and the genetic improvement of crop resistance.

planttranscription factorsendoplasmic reticulum stressUPRstress

白雨婷、张文晓、周倩、向凤宁

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山东大学生命科学学院,植物发育与环境适应生物学教育部重点实验室,山东青岛 266237

植物 转录因子 内质网胁迫 UPR 逆境胁迫

山东省重点研发计划山东省重点研发计划国家重点研发计划NSFC-山东联合基金国家科技创新2030—重大专项国家转基因重大专项国家转基因重大专项

2023LZGC0082021LZGC0032021YFF1001201U19062032023ZD0403601022018ZX08009-14B2016ZX08010002-009

2024

10.13592/j.cnki.ppj.300245

植物生理学报
中国植物生理学会，中国科学院上海生命科学研究院植物生理生态研究所

植物生理学报

CSTPCD北大核心
影响因子：1.532
ISSN：2095-1108
年,卷(期)：2024.60(7)