As a vital second messenger in eukaryotic cell,Ca2+almost participates in the transduction of all stimuli signals related to environment,growth and development.Various Ca2+decoders are evolved and confer plants to respond to these stimuli specifically and appropriately.Calmudulins/calmodulin-like pro-teins(CaMs/CMLs)family,which is considered as Ca2+sensor,plays important roles in plant growth and stress resistance.This paper reviews the current research progress on the protein structure,genetic evolu-tion,biological functions and acting molecular mechanism of CaMs/CMLs family,so as to provide refer-ence for the further research of Ca2+signaling.