The dual-action mechanism of Arabidopsis cryptochromes∞

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外文摘要：Photoreceptor cryptochromes(CRYs)mediate blue-light regulation of plant growth and development.It has been reported that Arabidopsis CRY1and CRY2 function by physically interacting with at least 84 proteins,including transcription factors or co-factors,chromatin regulators,splicing factors,messenger RNA methyltransferases,DNA repair proteins,E3 ubiquitin ligases,protein kinases and so on.Of these 84 proteins,47 have been reported to exhibit altered binding affinity to CRYs in response to blue light,and 41 have been shown to exhibit condensation to CRY photobodies.The blue light-regulated composition or condensation of CRY complexes results in changes of gene expression and developmental programs.In this mini-review,we analyzed recent studies of the photoregulatory mechanisms of Arabidopsis CRY complexes and proposed the dual mechanisms of action,including the"Lock-and-Key"and the"Liquid-Liquid Phase Separation(LLPS)"mechanisms.The dual CRY ac-tion mechanisms explain,at least partially,the structural diversity of CRY-interacting proteins and the functional diversity of the CRY photoreceptors.

外文关键词：

Arabidopsisblue lightcryptochromeCRY1CRY2phase separation

作者：

Gao-Ping Qu、Bochen Jiang、Chentao Lin

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作者单位：

Basic Forestry and Plant Proteomics Research Center,Fujian Agriculture and Forestry University,Fuzhou 350002,China

Department of Chemistry,Department of Biochemistry and Molecular Biology,Institute for Biophysical Dynamics,The University of Chicago,Chicago,IL 60637,USA

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationChina Postdoctoral Science Foundation

项目编号：

32330009320001552020M6705202021T140705

出版年：

2024

DOI：

10.1111/jipb.13578

植物学报(英文版)

中国植物学会

植物学报(英文版)

CSTPCD

影响因子：0.921

ISSN：1672-9072

年,卷(期)：2024.66(5)

参考文献量3