RACK1A promotes hypocotyl elongation by scaffolding light signaling components in Arabidopsis

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外文摘要：Plants deploy versatile scaffold proteins to intricately modulate complex cell signaling.Among these,RACK1A(Receptors for Activated C Kinase 1A)stands out as a multifaceted scaffold protein func-tioning as a central integrative hub for diverse sig-naling pathways.However,the precise mechanisms by which RACK1A orchestrates signal transduction to optimize seedling development remain largely unclear.Here,we demonstrate that RACK1A facilitates hypocotyl elongation by functioning as a flexible platform that connects multiple key compo-nents of light signaling pathways.RACK1A interacts with PHYTOCHROME INTERACTING FACTOR(PIF)3,enhances PIF3 binding to the promoter of BBX11 and down-regulates its transcription.Furthermore,RACK1A associates with ELONGATED HYPOCOTYL 5(HY5)to repress HY5 biochemical activity toward target genes,ultimately contributing to hypocotyl elongation.In darkness,RACK1A is targeted by CONSTITUTIVELY PHOTOMORPHOGENIC(COP)1 upon phosphorylation and subjected to COP1-mediated degradation via the 26 S proteasome system.Our findings provide new insights into how plants utilize scaffold proteins to regulate hypocotyl elongation,ensuring proper skoto-and photo-morphogenic development.

外文关键词：

Arabidopsishypocotyl developmentlight signaling componentsRACK1scaffold protein

作者：

Yajuan Fu、Wei Zhu、Yeling Zhou、Yujing Su、Zhiyong Li、Dayan Zhang、Dong Zhang、Jinyu Shen、Jiansheng Liang

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作者单位：

Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes,Department of Biology,School of Life Sciences,Institute of Plant and Food Sciences,Southern University of Science and Technology,Shenzhen 518055,China

基金：

National Natural science Foundation of ChinaShenzhen Science and Technology ProgramKey Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education InstitutesScientific Research Funding for postdoctoral researchers staying at ShenzhenScientific Research Funding for postdoctoral researchers staying at Shenzhen

项目编号：

32070292KQTD201909291739067422019KSYS006K19227561K21227504

出版年：

2024

DOI：

10.1111/jipb.13651

植物学报(英文版)

中国植物学会

植物学报(英文版)

CSTPCD

影响因子：0.921

ISSN：1672-9072

年,卷(期)：2024.66(5)

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