首页|Reading m6A marks in mRNA:A potent mechanism of gene regulation in plants
Reading m6A marks in mRNA:A potent mechanism of gene regulation in plants
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NETL
NSTL
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Modifications to RNA have recently been recog-nized as a pivotal regulator of gene expression in living organisms.More than 170 chemical mod-ifications have been identified in RNAs,with N6-methyladenosine(m6A)being the most abundant modification in eukaryotic mRNAs.The addition and removal of m6A marks are catalyzed by meth-yltransferases(referred to as"writers")and deme-thylases(referred to as"erasers"),respectively.In addition,the m6A marks in mRNAs are recognized and interpreted by m6A-binding proteins(referred to as"readers"),which regulate the fate of mRNAs,including stability,splicing,transport,and trans-lation.Therefore,exploring the mechanism under-lying the m6A reader-mediated modulation of RNA metabolism is essential for a much deeper under-standing of the epigenetic role of RNA modification in plants.Recent discoveries have improved our understanding of the functions of m6A readers in plant growth and development,stress response,and disease resistance.This review highlights the latest developments in m6A reader research,em-phasizing the diverse RNA-binding domains crucial for m6A reader function and the biological and cel-lular roles of m6A readers in the plant response to developmental and environmental signals.More-over,we propose and discuss the potential future research directions and challenges in identifying novel m6A readers and elucidating the cellular and mechanistic role of m6A readers in plants.
NETL
NSTL
万方数据
