Research Advance of PPR Proteins Involved in the Mechanism of Organelle RNA C→U Editing
Mitochondria and chloroplasts are semi-autonomous organelles harboring their own genomes.RNA editing is essential for the correct expression of organelle genes.The mostly identified RNA editing is cytidine(C)-to-uridine(U).Multiple editing factors have been reported to be involved in RNA C→U editing.The PPR-motifs array in PPR proteins specifically target editing sites,and the DYW domains in PPR-DYW proteins catalyze the deaminase in the C→U editing.This paper aims to review the recent advance of PPR proteins involved in RNA C→U editing,and to discuss the potential application value of synthetic PPR editing factors.
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