In the context of the intersection of diverse cultures,the integration of culture and art in interior design not only enhances the aesthetic value of the space,but also endows the space with profound cultural connotation and unique artistic atmosphere.Through the analysis of culture in interior design and art elements of the embodiment of the influence of interior design,discusses the design aesthetics theory,cultural semiotics and the application of cross-cultural exchange theory in interior design,further elaborated from the color application,material selection and space layout to realize the path of culture and art fusion,and through Chinese and western classic cases and examples in the modern city,shows the culture and art fusion in interior design successful practice,aims to provide theoretical and practice reference,to create interior design works with international vision and local characteristics.