Effects of Yishen Antai Huayu Recipe on Coagulation Indicators and Pregnancy Outcomes for Early Threatened Abortion Complicated Subchorionic Hematoma Patients with Shen Deficiency Blood Stasis Syndrome
Objective To retrospectively analyze the effects of Yishen Antai Huayu Recipe(YAHR)combined with progesterone on coagulation indicators and pregnancy outcomes for early threatened abortion complicated subchorionic hematoma(SCH)patients with Shen deficiency blood stasis syndrome(SDBSS).Methods Totally 92 early threatened abortion complicated SCH patients with SDBSS were assigned to observation group and control group according to whether they had used Chinese medicine(CM)after admission,46 cases in each group.The clinical efficacy,subchorionic hematoma area,estradiol(E2),progesterone(P),beta-human chorionic gonadotropin(β-HCG),coagulation indicators,and pregnancy outcomes were observed in the two groups.Results(1)Clinical efficacy,CM primary and secondary symptoms scores:The total clinical efficacy was 93.48％(43/46 cases)in the observation group and 52.17％(24/46 cases)in the control group,with insignificant difference between the two groups(x2=39.864,P＜0.01).The primary and secondary symptoms scores significantly decreased after 7 and 14 days of treatment in the observation group(P＜0.01).The scores of vaginal bleeding,frequent nocturia,and dark complexion decreased significantly after 14 days in the control group(P＜0.01).(2)SCH,SCH area/gestational sac area(SCH/GS area),E2,P,β-HCG,coagulation indicators,and uterine arterial resistance index:After 7 days of treatment,SCH,SCH/GS area,and resistance index(RI)significantly decreased(P＜0.05),E2 and β-HCG significantly increased(P＜0.05)in the observation group.SCH/GS significantly decreased(P＜0.05),E2 and β-HCG significantly increased(P＜0.05)in the control group.After 14 days of treatment SCH,SCH/GS area,D-dimer(D-D),adenosine diphosphate(ADP),and resistance index(RI)significantly decreased,E2,P,and β-HCG significantly increased(P＜0.05)in the observation group.SCH and SCH/GS area significantly decreased in the control group(P＜0.05).All the inter-group indicators were significantly better in the observation group than in the control group(P＜0.05).(3)The hospitalization days was(7.63±3.49)days in the observation group and(9.47±4.77)days in the control group.The time to stop vaginal bleeding was(3.17±2.14)days in the observation group and(4.41±2.05)days in the control group.The hospitalization days and the time to stop vaginal bleeding were significantly shorter in the observation group than in the control group(t1=2.122,t2=2.834,P＜0.05)(4)The full-term birth rate of the observation group[84.78％(39/46)]was higher than that of the control group[56.52％(26/46)].The premature birth rate[6.52％(3/46)]and the miscarriage rate[8.69％(4/46)]were lower in the observation group than in the control group[17.39％(8/46);26.09％(12/46)].There were statistical differences in term birth rate and abortion rate between the two groups(x21=4.842,P＜0.05;x22=8.859,P＜0.01).Conclusion YAHR combined with Dydrogesterone Injection and Progesterone Injection shortened the time of vaginal bleeding,promoted SCH absorption,improved blood coagulation function,reduced uterine artery resistance,promoted the secretion of P and β-HCG of early threatened abortion complicated SCH patients with SDBSS,thereby lowering the number hospitalization days,reducing the rates of miscarriage and premature delivery,and elevating the rate of full-term delivery.
Yishen Antai Huayu RecipeShen deficiency blood stasisthreatened abortion with subchorionic hematomacoagulation indicatorpregnancy outcomeintegrative medicine
国家科技期刊平台
NSTL
万方数据
维普
