Comparison of Clinical Efficacy of Tuoli Xiaodu Powder and Chaihu Qinggan Decoction in Treatment of Non-puerperal Mastitis patients with Intense Heat Induced Flesh Decay Syndrome at Early Stage of Abscess:A Randomized Controlled Trial
Objective To compare the clinical efficacy of Tuoli Xiaodu Powder(TLXDP)and Chaihu Qinggan Decoction(CHQGD)in the treatment of non-puerperal mastitis(NPM)patients with intense heat induced flesh decay syndrome(IHIFDS)at the early stage of abscess and their effects on the levels of relevant serum inflammatory indices.Methods A randomized,controlled,single-blind study method was used.Seventy-two early stage NPM patients with IHIFDS at the outpatient clinic were randomly assigned to the test group and the control group,36 in each group.Patients in the test group took TLXDP and those in the control group took CHQGD.The treatment course lasted for 28 days.Fasting blood was collected at early morning on the first,14th and 28th day of grouping.The size of the mass was also measured,and the degree of abscess formation and skin breakdown were recorded as well.Results The number and extent of abscess cavities were greater in the test group on the 14th day of treatment,and the number and extent of surface ulceration of abscesses were more severe(P＜0.05).On the 28th day of treatment the masses in the test group were significantly smaller than those in the control group(P＜0.05).Post-treatment abnormally increased erythrocyte sedimentation rate(ESR)decreased to a better level in the test group than in the control group(P＜0.05).Immune dysfunction in early stage NPM patients was manifested by abnormally increased immunoglobulin G(IgG),complement 4(C4),CD3+T lymphocytes(CD3+),CD4+T lymphocytes(CD4+),regulatory T cells(Treg),and CD19+B lymphocytes(CD19+),and abnormally decreased complement 3(C3),human leucocyte antigen DR(HLA-DR),and natural killer cell(NK).All abnormal parameters tended to be normal after treatment.The regulatory effect on HLA-DR T cells was stronger in the test group(P＜0.05).Conclusion Compared with CHQGD,TLXDP was better in promoting mass reduction,anti-inflammation,and immunomodulation in the treatment of early stage NPM.
non-puerperal mastitis at the early stage of abscessTuoli Xiaodu PowderChaihu Qinggan Decoctionintense heat induced flesh decay syndromerandomized controlled trialChinese herbal compound
国家科技期刊平台
NSTL
万方数据
维普
