首页|从细胞衰老视角论中医药防治糖尿病心肌病

从细胞衰老视角论中医药防治糖尿病心肌病

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
糖尿病心肌病是糖尿病心脏病主要并发症。笔者从糖脂代谢导致的代谢稳态失衡为主线，以细胞衰老为切入点，全面梳理糖尿病心肌病不同阶段病机演变特点，总结出因虚致衰是始动环节，因毒致衰是加重因素，因瘀致衰是表现形式。围绕细胞衰老提出病证结合指导下的防治策略，认为未病先防理念下的主动健康模式是关口前移的根本，借助现代生物信息技术，形成不同阶段的"病-证-时-方"个体诊疗方案是关键，联合多组学技术阐明细胞衰老不同阶段证候学实质是抓手。为糖尿病心肌病防治提供新视角。
Prevention and Treatment of Diabetic Cardiomyopathy by Chinese Medicine from the Cellular Senescence Perspective
Diabetic cardiomyopathy is a major cardiovascular complication of diabetes mellitus.This paper focuses on the imbalance of metabolism homeostasis caused by glucose and lipid metabolism,and takes cellular senescence as the entry point to comprehensively sort out the characteristics of the evolution of diabetic cardiomyopathy at different stages of the pathogenesis,and summarizes that the decline due to deficiency is the starting link,the decline due to toxin is the causative factor,and the decline due to blood stasis is the form of manifestation.The prevention and treatment strategy under the guidance of disease-syndrome combination is proposed around cellular senescence,and it is considered that the active health model under the concept of prevention before disease is the fundamental key to move the gate forward,the formation of individual diagnosis and treatment plan of"disease-evidence-time-prescription"at different stages with the help of modern bioinformatics technology is the key,and the elucidation of the evidence substance at different stages of cellular senescence with the combination of multi-histology technology is the key to the development.This paper provides a new perspective for the prevention and treatment of diabetic cardiomyopathy.

diabetic cardiomyopathyvascular homeostasisglucose and lipid metabolismcellular senescencetreatment strategyChinese medicine

漆仲文、赵俊男、张艳虹、王青、刘玥、徐凤芹

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中国中医科学院老年医学研究所(北京 100091)

中国中医科学院博士后科研流动站(北京 100091)

国家中医药管理局病证结合防治血管衰老重点研究室(北京 100091)

中国中医科学院西苑医院国家中医心血管病临床医学研究中心(北京 100091)

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糖尿病心肌病 血管稳态 糖脂代谢 细胞衰老 防治策略 中医药

中国博士后科学基金项目国家中医药管理局中医药传承与创新"百千万"人才工程-岐黄学者项目国家中医药管理局中医药循证能力建设项目

2023M73391502045006ZZ13-024-4

2024

10.7661/j.cjim.20231229.262

中国中西医结合杂志
中国中西医结合学会 中国中医科学院

中国中西医结合杂志

CSTPCD北大核心
影响因子：2.149
ISSN：1003-5370
年,卷(期)：2024.44(2)
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