Kaiyin Mixture of Spica prunellae Improves the Voice and Quality of Life after Laser Surgery for Early Glottic Laryngeal Carcinoma:A Randomized Controlled Trial
Objective To observe the effect of Kaiyin Mixture of Spica prunellae on voice and quality of life of patients with early glottic laryngeal cancer after CO2 laser surgery.Methods A total of 52 patients with stage T1a glottic laryngeal carcinoma who visited Shanghai First People's Hospital from September 2019 to June 2021 were randomly assigned to treatment group(26 cases)and control group(26 cases)according to random number.Both groups received type Ⅲ-Ⅴa CO2 laser,the treatment group received Kaiyin Mixture of Spica prunellae,and the control group received placebo,each taking a course of treatment(3 months),supplemented by voice training,and followed up for 6 months.The voice acoustic analysis,voice handicap index and Quality of Life Scale were collected at 1,3 and 6 months after operation for observation and comparison.Results There was no significant difference in the indicators between two groups at 1 month after surgery(P＞0.05).At 3 months after surgery,the normalized noise energy(NNE),harmonics to noise ratio(NHR)and the scores in the"physiological"category of the voice handicap index(VHI)scale of the treatment group,were better than those of the control group(P＜0.05).At 6 months after surgery,the data of Jitter,Shimmer,NNE,HNR,VHI scale and quality of life score of the treatment group were better than those of the control group(P＜0.05).Conclusion Kaiyin Mixture of Spica prunellae could improve the voice and quality of life of patients with early glottic laryngeal cancer after CO2 laser surgery.
T1a glottic laryngeal carcinomaKaiyin mixture of Spica prunellaevoicequality of lifeChinese herbal medicineintegrative medicine
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