Experimental Study on Electrophysiological Changes of Sick Sinus Syndrome Model Rats with Intervention of Shenglu Decoction
Objective To study the effects of Shenglu Decoction(SLD)in electrophysiological function of sinoatrial node in sick sinus model rats,and explore the mechanism.Methods Forty sick sinus model rats were randomly divided into model group,SLD high,low dose and aminophylline groups,10 in each group.The other 10 rats were selected as sham group.The sham and model groups were given intragastric administration of physiological saline as 5 mL/d,the SLD high and low dose groups were given intragastric administration of SLD as 30.24 and 7.56 g·kg-1.The aminophylline group was given aminophylline as 80 mg·kg-1.Typical electrocardiograms were recorded before and after intervention.AA interval,sinus node recovery time(SNRT),corrected sinus node recovery time(CSNRT),and sinoatrial conduction time(SACT)were compared among different groups.Results Compared with the sham group,the AA interval,SNRT,CSNRT and SACT in the model group were significantly prolonged(P＜0.05).Compared with the model group,the AA interval,SNRT,CSNRT and SACT were significantly shortened in the SLD high dose and aminophylline groups after intervention(P＜0.05).Compared with the aminophylline group,the AA interval,SNRT and SACT were SLD high dose group after intervention(P＜0.05).Conclusion The high dose SLD could significantly improve the electrophysiological function of sinoatrial node in sick sinus model rats.
Shenglu Decoctionsick sinus syndromeelectrophysiological function of sinus nodeChinese herbal compoundaminophylline
国家科技期刊平台
NSTL
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