首页|经皮穴位电刺激对早期肺癌患者麻醉诱导期血流动力学和麻醉药用量影响随机对照研究

经皮穴位电刺激对早期肺癌患者麻醉诱导期血流动力学和麻醉药用量影响随机对照研究

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原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 探讨经皮穴位电刺激(TEAS)对早期肺癌患者行胸腔镜肺切除术时血流动力学和术中麻醉药用量的影响。方法 纳入拟择期行胸腔镜肺切除术的早期肺癌患者70例，采用随机数字表法分为TEAS组和对照组，每组35例。TEAS组患者术前30 min于双侧内关和曲池穴行TEAS，频率为2/100 Hz，持续至手术结束;对照组在相应穴位贴上电极片，但不予电刺激。两组患者麻醉方式和术中用药原则相同。记录两组患者术前(T0)、麻醉诱导后(T1)、气管插管后即刻(T2)和气管插管后5 min(T3)血压和心率。观察术中麻醉药物(包括丙泊酚，瑞芬太尼和罗库溴铵)用量，记录术中不良心血管事件，术后头晕、恶心、呕吐的发生率和术后复苏时间。结果 与对照组比较，TEAS组患者气管插管后即刻的血压和心率降低[对照组平均动脉压:(103±6)mmHg，TEAS组平均动脉压:(94±7)mmHg，P=0。001;对照组心率:(91±8)次/分，TEAS组心率:(80±10)次/分，P=0。001]，术中瑞芬太尼的用量减少[对照组:(1。18±0。48)mg，TEAS组:(0。89±0。32)mg，P=0。004]，术后复苏时间缩短[对照组:(53。2±6。8)min，TEAS组:(46。2±6。0)min，P=0。001]。结论 TEAS有助于维持早期肺癌患者行胸腔镜肺切除术时麻醉诱导期血流动力学稳定，减少术中麻醉药的用量，缩短复苏时间。(中国临床试验注册中心 No。ChiCTR2200057529)
Hemodynamic Stability during Anesthesia Induction and Dosage of Anesthetics in Patients with Early-Stage Lung Cancer:A Randomized Controlled Trial
Objective To explore the effect of transcutaneous electrical acupoint stimulation(TEAS)on hemodynamic stability and dosage of anesthetics in patients with early-stage lung cancer.Methods Totally 70 patients undergoing video-assisted thoracic surgery because of lung cancer were recruited and randomly assigned to the TEAS group and the control group using the random number table,35 cases in each group.For patients in the TEAS group,electrical stimulation was started 30 min before surgery at bilateral Neiguan(PC6)and Quchi(LI11)acupoint with a frequency of 2/100 Hz and ended till the operation was finished.In the control group,electrodes were connected to the two acupoints without electrical stimulation.The same anesthesia technique and principal of medication were applied in all the patients recruited.Blood pressure and heart rate before anesthesia(T0),after anesthesia induction(T1),immediately after intubation(T2)and 5 min after intubation(T3)were recorded.Dosage of anesthetic drugs(including propofol,remifentanil and rocuronium bromide)were observed.The incidence of adverse cardiovascular events,postoperative dizziness,nausea,vomiting and time of stay in the postanesthesia care unit(PACU)were recorded.Results Compared with the control group,patients in TEAS group showed a significant lower blood pressure and heart rate right after intubation[(103±6)mmHg vs(94±7)mmHg,P=0.001;(91±8)bpm vs(80±10)bpm,P=0.001].The dosage of intraoperative remifentanil[(1.18±0.48)mg vs(0.89±0.32)mg,P=0.004)]and time of stay in PACU(53.2±6.8)min vs(46.2±6.0)min,P=0.001]were significantly reduced.Conclusion TEAS helps to maintain hemodynamic stability during anesthesia induction,reduces dosage of anesthetic and shortens the time of stay in PACU among patients undergoing video-assisted thoracic surgery diagnosed with early-stage lung cancer.(China Clinical Trial Registry No.ChiCTR2200057529)

transcutaneous electrical acupoint stimulationearly-stage lung cancervideo-assisted thoracic surgeryhemodynamic stabilityintegrative medicineNeiguan(PC6)Quchi(LI11)randomized controlled trial

刘洁、刘慧慧、吴财能、马武华

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广州中医药大学第一附属医院麻醉科(广州 510405)

经皮穴位电刺激 早期肺癌 胸腔镜肺切除术 血流动力学 中西医结合 内关 曲池 随机对照试验

广东省中医药局科研面上项目国家自然科学基金

2022205082374451

2024

10.7661/j.cjim.20240624.027

中国中西医结合杂志
中国中西医结合学会 中国中医科学院

中国中西医结合杂志

CSTPCD北大核心
影响因子：2.149
ISSN：1003-5370
年,卷(期)：2024.44(8)