Taking Huanglian Decoction Thrice by day and Twice by Night on Sepsis-Related Acquired Weakness:A Randomized Controlled Trial
Objective To observe the clinical efficacy of taking Huanglian Decoction(HD)thrice by day and twice by night on sepsis-related acquired weakness.Methods Sixty patients with sepsis-related acquired weakness in department of intensive care unit(ICU),the second affiliated hospital of Nanjing University of Chinese Medicine from January 2023 to May 2024 were enrolled in this study and randomly assigned to into control group,HD group and HD control group,with 20 cases in each group.All three groups were given the conventional nutritional support program,the HD group took HD thrice by day and twice by night,and the HD control group was given HD twice in the morning and evening,and the treatment lasted for 14 days.Biceps brachii muscle thickness,rectus femoris muscle thickness,diaphragmatic excursion,and diaphragmatic thickening fraction were measured before and after treatment.Serum hemoglobin,albumin,and prealbumin levels were measured.The 28 d and 90 d survival rates for each group of patients were calculated.Results Totally 2 cases dropped out in HD group,and 1 case dropped out in HD control group.Compared with the group before treatment,rectus femoris muscle thickness,diaphragmatic excursion in 7 d of treatment,biceps brachii muscle thickness,rectus femoris muscle thickness,diaphragmatic excursion,and diaphragmatic thickening fraction in 7 d and 14 d of treatment,serum albumin,and prealbumin levels in 14 d of treatment increased in control group and HD control group(P＜0.05).Biceps brachii muscle thickness,rectus femoris muscle thickness,diaphragmatic excursion,and diaphragmatic thickening fraction in 7 d and 14 d of treatment,serum albumin,and prealbumin in 14 d of treatment increased in HD group(P＜0.05).Compared with the control group at the same time,rectus femoris muscle thickness,serum hemoglobin and prealbumin in 14 d of treatment,diaphragmatic excursion in 7 d and 14 d of treatment increased in HD control group(P＜0.05).Biceps brachii muscle thickness,rectus femoris muscle thickness,diaphragmatic excursion,and diaphragmatic thickening fraction in 7 d and 14 d of treatment,serum hemoglobin,albumin,and prealbumin in 14 d of treatment increased in HD group(P＜0.05).Compared with HD control group at the same time,rectus femoris muscle thickness,diaphragmatic excursion in 7 d of treatment,biceps brachii muscle thickness,rectus femoris muscle thickness,diaphragmatic excursion in 7 d and 14 d of treatment,serum hemoglobin,albumin,and prealbumin in 14 d of treatment increased in HD group(P＜0.05).Compared with the control group,there was no statistically significant difference in the 28 d and 90 d survival rates in HD control group(P＞0.05),the 28 d and 90 d survival rates increased in HD group(P＜0.05).Compared with HD control group,there was no statistically significant difference in 28 d and 90d survival rates in HD group(P＞0.05).Conclusions Taking HD thrice by day and twice by night can improve the limb atrophy and diaphragm dysfunction of patients,improve the nutritional status of the body,and may improve the survival rate of hospitalized patients.(International Traditional Medicine Clinical Trial Registry,No.ITMCTR2024000045)
Huanglian Decoctionthrice by day and twice by nighttime-sharing administrationsepsisacquired weakness Chinese herbal compoundintegrative medicinerandomized controlled trial
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