Huang'e Capsules Combined with Tamsulosin in the Treatment of Prostate Hyperplasia Combined with Chronic Prostatitis:A Randomized Controlled Study
Objective To compare the clinical efficacy of Huang'e Capsules(HC)combined with tamsulosin in the treatment of benign prostatic hyperplasia(BPH)combined with prostatitis(CP).Methods A total of 150 patients diagnosed with BPH combined with CP were randomly assigned to tamsulosin group,HC group,and combination group,with 50 patients in each group.The tamsulosin group received oral tamsulosin 0.2 mg per night.The HC group received oral HC,4 capsules per time,3 times per day.The combination group received both tamsulosin and HC.The main therapeutic index included prostate volume,prostate symptoms assessed by International Prostate Symptom Scale(IPSS).The secondary efficacy index included Chinese medicine(CM)symptom score,maximum flow rate(Qmax),National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI),Quality of Life score(QOL).The adverse reactions were observed in the 3 groups.Results Totally 42 cases in tamsulosin group,41 cases in HC group,40 cases in combination group finished the study,and included in the statistical analysis.Compared with before treatment in the same group,IPSS,CM symptom score,QOL,total score,discomfort symptom,urination symptom,life treatment,symptom severity score of NIH-CPSI decreased,Qmax increased after treatment in all groups(P＜0.05).Prostate volume decreased after treatment in HC group and combination group(P＜0.05).Compared with tamsulosin group and HC group at the same time,IPSS,CM symptom score,QOL,total score,discomfort symptom,urination symptom,life treatment score of NIH-CPSI decreased,Qmax increased after treatment in combination group(P＜0.05).There was no statistical significance in adverse reaction between the 3 groups(P＞0.05).Conclusion The combination of HC and tamsulosin improve prostate symptoms,quality of life,and CM symptom score in the treatment of BPH combined with CP patients.
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