首页|Iridoids modulate inflammation in diabetic kidney disease:A review

Iridoids modulate inflammation in diabetic kidney disease:A review

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In recent years,preclinical research on diabetic kidney disease(DKD)has surged to the forefront of sci-entific and clinical attention.DKD has become a pervasive complication of type 2 diabetes.Given the complexity of its etiology and pathological mechanisms,current interventions,including drugs,dietary modifications,exercise,hypoglycemic treatments and lipid-lowering methods,often fall short in achiev-ing desired therapeutic outcomes.Iridoids,primarily derived from the potent components of traditional herbs,have been the subject of long-standing research.Preclinical data suggest that iridoids possess notable renal protective properties;however,there has been no summary of the research on their efficacy in the management and treatment of DKD.This article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this condition.Additionally,it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora,potentially bolstering their therapeutic effects.This review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD,offering valuable insights for future research endeavors.

Diabetic kidney diseaseIridoidsGut-kidney axisTraditional Chinese medicine monomerInflammation

Tong-yi Zhou、Na Tian、Liu Li、Rong Yu

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The First Clinical College of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,Hunan Province,China

Hunan Provincial Key Laboratory of Translational Research in Traditional Chinese Medicine Prescriptions and Zheng,Changsha 410208,Hunan Province,China

National Natural Science Foundation of Chinakey projects supported by the National Natural Science Foundation of China and Joint Fund for Regional Innovation and Developmen

82074400U21A20411

2024

10.1016/j.joim.2024.03.010

结合医学学报(英文版)
上海市中西医结合学会,上海长海医院

结合医学学报(英文版)

CSTPCD
影响因子：0.711
ISSN：2095-4964
年,卷(期)：2024.22(3)
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