首页|Effects of acupuncture on hypothalamic-pituitary-adrenal axis:Current status and future perspectives
Effects of acupuncture on hypothalamic-pituitary-adrenal axis:Current status and future perspectives
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The hypothalamic-pituitary-adrenal(HPA)axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes.Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium,resulting in impaired physiological functions.Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis.With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders,a comprehensive review in terms of the underlying molecular mechanism for acupuncture,especially in regulating the HPA axis,is currently in need.This review fills the need and summarizes recent breakthroughs,from the basic principles and the pathological changes of HPA axis dysfunction,to the molecular mechanisms by which acupuncture regulates the HPA axis.These mechanisms include the modulation of multiple neurotransmitters and their receptors,neuropeptides and their receptors,and microRNAs in the paraventricular nucleus,hippocampus,amygdala and pituitary gland,which alleviate the hyperfunctioning of the HPA axis.This review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunc-tion for the first time,providing new targets and prospects for further exploration of acupuncture.
Department of Integrative Medicine and Neurobiology,School of Basic Medical Sciences,State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science,Institutes of Brain Science,Institute of Acupuncture Research,Academy of Integrative Medicine,Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function,Shanghai Medical College,Fudan University,Shanghai 200032,China
Department of Human Anatomy,School of Integrative Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaInnovative Research Team of Highlevel Local Universities in ShanghaiShanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function
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