Abstract
Obesity,a widespread global health issue,is frequently linked to disrupted lipid metabolism,resulting in excessive accumulation of adipose tissue and associated health complications.Acupuncture,a traditional Chinese medical modality,has exhibited potential as a viable intervention for addressing obesity.The underlying mechanism proposed involves the stimulation of specific acupoints to exert a regulatory influ-ence on hepatic function.The liver has a central role in lipid metabolism,including processes such as lipid synthesis,storage and distribution.Acupuncture is believed to enhance the liver's efficiency in processing lipids,thereby reducing lipid accumulation and improving metabolic functions.Research indicates that acupuncture can influence the expression of certain genes and proteins involved in lipid metabolism in the liver.This includes upregulating genes that promote lipid breakdown and oxidation,and downreg-ulating those involved in lipid synthesis.Additionally,acupuncture has been shown to improve insulin sensitivity,which is crucial for the regulation of lipid metabolism.Furthermore,the potential anti-inflammatory effects of acupuncture may play a significant role in its efficacy for the treatment of obesity.The presence of chronic inflammation has been strongly associated with metabolic disorders such as obe-sity.Through its ability to mitigate inflammation,acupuncture can potentially aid in the restoration of lipid metabolism and the reduction of body weight.Moreover,the amelioration of hepatic oxidative stress represents another mechanism by which acupuncture may contribute to the reduction of lipid deposition.Notably,the liver,being the primary site of lipid metabolism,maintains communication with various organs including the brain,adipose tissue,skeletal muscle and intestines.This perspective opens new avenues for the treatment of obesity,emphasizing the importance of holistic approaches in manag-ing complex metabolic disorders.
维普
万方数据