Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines

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外文摘要：Objective:Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative medicine.The physicochemical properties and biological activity of these preparations are often investigated in preclinical research,yet no guidelines for experimental research currently exist in this area.The present PrePoP guidelines aim to provide recommendations to promote high-quality,statistically sound,and reproducible preclinical research on potentised preparations.Methods:Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls,sample preparation and handling,and statistics.After three rounds of feedback,a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised preparations.Results:We present a series of recommendations on a range of topics including experimental controls,system stability,blinding and randomisation,environmental influences,and procedures for the prepara-tion of potentised samples and controls,and we address some specific challenges of this research field.Conclusion:This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

外文关键词：

Research guidelinesFundamental researchBasic researchComplementary and integrative medicinePotentisationPotentised preparations

作者：

Alexander L.Tournier、Leoni V.Bonamin、Susann Buchheim-Schmidt、Steven Cartwright、Christoph Dombrowsky、Paul Doesburg、Carla Holandino、Maria Olga Kokornaczyk、Everine B.van de Kraats、Jesús Antonio López-Carvallo、Papiya Nandy、José Manuel Mazón-Suástegui、Fateme Mirzajani、Bernard Poitevin、Claudia Scherr、Karin Thieves、Sandra Würtenberger、Stephan Baumgartner

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作者单位：

Institute of Complementary and Integrative Medicine,University of Bern,3010 Bern,Bern,Switzerland

Institute of Integrative Medicine,Witten/Herdecke University,58455 Witten,North Rhine-Westphalia,Germany

Homeopathy Research Institute,London SW7 4EF,United Kingdom

Graduate Program on Environmental and Experimental Pathology,Paulista University,São Paulo 01504-000,São Paulo,Brazil

Department of Medical Science,Deutsche Homöopathie-Union DHU-Arzneimittel GmbH & Co.KG,76227 Karlsruhe,Baden-Württemberg,Germany

Cherwell Laboratory for Fundamental Research in Homeopathy,Oxford OX2 8NU,Oxforeshire,United Kingdom

Society for Cancer Research,Hiscia Research Institute,4144 Arlesheim,Basel,Switzerland

Laboratório Multidisciplinar de Ciências Farmacêuticas,Universidade Federal do Rio de Janeiro,Rio de Janeiro 21941-902,Rio de Janeiro,Brazil

World Water Community,Rotterdam 3029AK,the Netherlands

Departamento de Acuicultura,Facultad de Ciencias del Mar,Universidad Católica del Norte,1790437 Coquimbo,Elqui,Chile

Centre for Interdisciplinary Research and Education,Kolkata,West Bengal 700068,West Bengal,India

Laboratorio de Homeopatía Acuícola y Semillas Marinas,Centro de Investigaciones Biológicas del Noroeste,La Paz 23096,Baja California Sur,Mexico

Protein Research Center,Shahid Beheshti University,Tehran 1983969411,Iran

Department of Medical Laboratory Science,College of Science,Knowledge University,44001 Erbil,Erbil,Iraq

Société Savante d'Homéopathie,75009 Paris,France

Sola Salus,Institute for Homeopathic Research,52511 Geilenkirchen,North Rhine-Westphalia,Germany

Scientific Society for Homeopathy,06366 Köthen,Saxony-Anhalt,Germany

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出版年：

2024

DOI：

10.1016/j.joim.2024.06.005

结合医学学报(英文版)

上海市中西医结合学会,上海长海医院

结合医学学报(英文版)

CSTPCD

影响因子：0.711

ISSN：2095-4964

年,卷(期)：2024.22(5)