首页|A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin
A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin
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A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin
Natural product-based antiviral candidates have received significant attention.However,there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug resistance.Baicalein and its glucuronide derivative baicalin are two main components extracted from Scutellaria baicalensis Georgi.They have proven to be effective against a broad range of viruses by directly killing virus particles,pro-tecting infected cells,and targeting viral antigens on their surface,among other mechanisms.As natural products,they both possess the advantage of lower toxicity,enhanced therapeutic efficacy,and even antagonistic effects against drug-resistant viral strains.Baicalein and baicalin exhibit promising potential as potent pharmacophore scaffolds,demonstrating their antiviral properties.However,to date,no review on the antiviral effects of baicalein and baicalin has been published.This review summarizes the recent research progress on antiviral effects of baicalein and baicalin against various types of viruses both in vitro and in vivo with a focus on the dosages and underlying mechanisms.The aim is to provide a basis for the rational development and utilization of baicalein and baicalin,as well as to promote antiviral drug research.
BaicalinBaicaleinAntiviral effectsInfluenza virusFlavivirusHepatitis B virusMechanism
Xin-yang Liu、Wei Xie、He-yang Zhou、Hui-qing Zhang、Yong-sheng Jin
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School of Basic Medicine,Naval Medical University,Shanghai 200433,China
Faculty of Traditional Chinese Medicine,Naval Medical University,Shanghai 200433,China
School of Pharmacy,Naval Medical University,Shanghai 200433,China
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