Clinical Study on Jiaotai Pill in the Treatment of Polycystic Ovary Syndrome with Anxiety and Depression
Objective To explore the clinical efficacy of Jiaotai Pill in treating polycystic ovary syndrome(P-COS)with anxiety and depression.Methods Sixty patients with PCOS accompanied by anxiety and depression were selected and randomly divided into the control group and the treatment group,with 30 cases in each group.The control group was given oral treatment with metformin tablets,while the treatment group was given Chinese herbal granules Jiaotai Pill on the basis of the control group.Both groups received continuous intervention for 12 weeks.The changes in indicators such as glucose and lipid metabolism,sex hormones,neurotransmitters,as well as anxiety,depression,and sleep scores in the two groups before and after treatment were compared.Results After treatment,the levels of fasting blood glucose(FBG),fasting insulin(FINS),total cholesterol(TC),and tri-glycerides(TG)in both groups decreased compared to those before treatment(P all＜0.05),and the TG and FINS in the treatment group were significantly lower than those in the control group(P all＜0.05).Luteinizing hormone(LH),testosterone(T),and LH/FSH ratio decreased in both groups compared to before treatment(P all＜0.05),and T and LH/FSH decreased more significantly in the treatment group(P all＜0.05).The self-rating anxiety scale(SAS)scores in the control group decreased compared to those before treatment(P＜0.05),while the SAS,self-rating depression scale(SDS)and Pittsburgh sleep quality index(PSQI)scores in the treatment group decreased compared to those before treatment(P all＜0.05),and the treatment group showed a more significant decrease(P all＜0.05).The levels of γ-aminobutyric acid(GABA)in the control group decreased compared to those before treatment(P＜0.05),while 5-hydroxytryptamine(5-HT)and GABA in the treatment group decreased compared to those before treatment(P all＜0.05),and the above indicators decreased more significantly in the treatment group compared to the control group(P all＜0.05).Conclusion Both Jiaotai Pill and metformin could obviously improve the glucose and lipid metabolism and sex hormone level of PCOS patients.Compared with using metformin alone,the combination of Jiaotai Pill and metformin had more obvious effects on TG,FINS,T and LH/FSH.In addition,it could obviously improve the anxiety and depression scores and sleep quality of patients,and its mechanism may be related to regulating the secretion of neurotransmitters GABA and 5-HT.
polycystic ovary syndromeJiaotai Pillanxietydepressionglucose and lipid metabolismneuro-transmitter
万方数据
维普
