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清肺化痰方治疗老年社区获得性肺炎临床研究

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目的 探讨清肺化痰方治疗老年社区获得性肺炎的临床疗效.方法 选取84例老年社区获得性肺炎患者,将其随机分为对照组和治疗组,每组4 2例.对照组予以莫西沙星治疗,治疗组在对照组基础上予以中药清肺化痰方治疗.2组均治疗14d.比较2组发热、咳嗽、咯痰、肺部啰音以及胸部X线片阴影等的消失时间,测定并比较2组治疗前后白细胞计数(white blood-cell count,WBC)、C反应蛋白(C reactive protein,CRP)、白介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)等炎症指标变化,同时比较2组临床总有效率及不良反应发生情况.结果 治疗后,治疗组总有效率为92.86%,对照组总有效率为66.67%;组间比较,差异具有统计学意义(P<0.05).治疗组发热、咳嗽、咯痰、肺部啰音、胸部X线片阴影等的消失时间明显短于对照组(P均<0.01).2组 WBC、CRP、IL-6、PCT等炎症因子水平均较前降低(P均<0.01),且治疗组上述指标明显低于对照组(P均<0.01).2组不良反应总发生率组间比较,差异无统计学意义(P>0.05).结论 清肺化痰方治疗老年社区获得性肺炎临床疗效确切,能明显改善临床症状,并降低炎症因子水平.
Clinical Study on Qingfei Huatan Formula in the Treatment of Elderly Community Acquired Pneumonia
Objective To explore the clinical efficacy of Qingfei Huatan formula in the treatment of elderly community acquired pneumonia.Methods A total of 84 elderly patients with community acquired pneumonia were selected and randomly divided into the control group and the treatment group,with 42 cases in each group.The control group was treated with moxifloxacin,while the treatment group was treated with traditional Chinese medi-cine Qingfei Huatan formula on the basis of the control group.Both groups were treated for 14 days.The disap-pearance time of fever,cough,sputum,lung rales,and chest X-ray shadows in two groups were compared.The changes of inflammatory indicators such as white blood-cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)before and after treatment were measured and compared.At the same time,the total clinical effective rate and incidence of adverse reactions in the two groups were also compared.Results After treat-ment,the total effective rate of the treatment group was 92.86%,and the total effective rate of the control group was 66.67%.The difference between the two groups was statistically significant(P<0.05).The disappearance time of fever,cough,sputum,lung rales,and chest X-ray shadows in the treatment group were significantly shorter than those in the control group(P all<0.01).The levels of inflammatory factors such as WBC,CRP,IL-6,and PCT in both groups were all lower than before(P all<0.01),and the above indicators in the treatment group were significantly lower than those in the control group(P all<0.01).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Qingfei Huatan formula had a definite clinical efficacy in the treatment of elderly community acquired pneumonia,which could significantly improve clinical symptoms and reduce the levels of inflammatory factors.

Qingfei Huatan formulacommunity acquired pneumoniaintegrated traditional Chinese and west-ern medicineinflammatory factors

职小飞、李相中

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安阳市殷都区人民医院内分泌科,河南安阳 455003

安阳市职业技术学院医药卫生学院,河南安阳 455003

清肺化痰方 社区获得性肺炎 中西医结合 炎症因子

河南省科技厅科技发展计划项目

192102310434

2024

中西医结合研究
华中科技大学

中西医结合研究

影响因子:0.649
ISSN:1674-4616
年,卷(期):2024.16(1)
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