Clinical Study on Sanbu Zhuluan Formula Combined with Qilin Needle in the Treatment of Premature Ovarian Insufficiency
Objective To explore the clinical efficacy of Sanbu Zhuluan formula combined with Qilin needle in the treatment of premature ovarian insufficiency(POI).Methods Eighty POI patients who were treated in our hospital from December 2021 to June 2023 were divided into the treatment group and the control group according to the random number table method,with 40 cases in each group.Patients in the control group were treated with com-plex packing estradiol tablets/estradiol dydrogesterone tablets for oral administration,while patients in the treat-ment group were treated with Sanbu Zhuluan formula combined with Qilin needle on the basis of the treatment in the control group.Twenty-eight days were regarded as one course of treatment,and both groups of patients re-ceived continuous treatment for three courses.The clinical efficacy of the two groups of patients,the traditional Chinese medicine syndrome score,serum follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),anti-Müllerian hormone(AMH),and ovarian basal antral follicle count(AFC)between two groups of patients before and after treatment were compared.Results After treatment,the total effective rate of patients in the treat-ment group was significantly higher than that in the control group(P＜0.05).The traditional Chinese medicine syndrome scores in the treatment group were significantly lower than those in the control group(P＜0.05).The se-rum levels of FSH and LH in the treatment group were significantly lower than those in the control group(P＜0.05),and the serum levels of E2 and AMH levels were significantly higher than those in the control group(P＜0.05).The ovarian basal AFC in the treatment group were significantly higher than those in the control group(P＜0.05).Conclusion Sanbu Zhuluan formula combined with Qilin needle could significantly alleviate clinical symp-toms of POI patients,increase the number of follicles,regulate the level of sex hormones,and improve the clinical efficacy.
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