Analysis of the Effect of Ultrafiltration Process on the Effective Components of Xiangdan Injection
Objective To clarify the differences in effective components in Xiangdan injection under different ultrafiltration conditions,and to determine the optimal conditions for the ultrafiltration process of Xiangdan injec-tion.Methods The orthogonal experimental design was adopted,with the pressure difference between the inlet and outlet of the ultrafiltration device,the temperature of the medication,the p H value of the medication,and the molecular weight of the ultrafiltration membrane as factors.The transmittance of Danshensu and Protocatechualde-hyde content in Xiangdan injection was used as the indicator,the differences in the effective components of Xiang-dan injection under various experimental conditions of ultrafiltration process were evaluated.Results The factors affect the ultrafiltration process of Danshensu and Protocatechualdehyde were basically the same.The molecular weight of the ultrafiltration membrane has a significant influence on the effective components of Xiangdan injection(P<0.05),while the influence of other factors was not significant(P>0.05).Conclusion The optimized ultrafil-tration process has little effect on the effective components in Xiangdan injection,was relatively stable,and has strong applicability.