首页|Cell-supplemented autologous fat grafting:a review from bench to bedside
Cell-supplemented autologous fat grafting:a review from bench to bedside
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Autologous fat grafting is routinely used in plastic and reconstructive surgery to improve contour deformities and appearance.However,retention of fat over time is inconsistent and unpredictable.Cell-assisted lipostransfer(CAL),the practice of using stem cell-containing portions of adipose to enrich fat grafts,has been found to be a promising area of research to increase not only the retention of volume but also increase collagen production,enhance angiogenesis,and direct the overall repair,remodeling,and regeneration of the recipient site.CAL,therefore,has a multitude of clinical applications,ranging from oncologic reconstruction following radiation to facial rejuvenation,among others.In this paper,we provide a comprehensive review of the current state of cell-supplemented fat transfer and discuss our understanding of cellular interactions in enriched fat grafts,techniques to improve the viability of fat,clinical translation of CAL,regulatory oversight,and future directions.
Cell-assisted lipotransferadipose-derived stem cellsautologous fat graftingregenerative medicine
Kanad Ghosh、Ronak A.Patel、Summer E.Hanson
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Department of Surgery,The University of Chicago Medicine and Biological Sciences Division,Chicago,IL 60631,US
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