Yangtze River economic zone,as China's key strategic zone,is closely related to national development by its ecological restoration and resources use.Jiangsu's chemical industry,an intensive polluting and resources-depleting industry,needs to properly handle industrial development and resources & environmental protection,which is of significance to protect Yangtze River and realize carbon reduction.This paper establishes a multiple-objective optimization model of chemical industry under dual constraints of carbon reduction and water ecological carrying capacity,and applies NSGA-Ⅱ-VIKOR algorithm to discuss the way to adjust Jiangsu's chemical industrial structure.Balanced development scenario,compared with low-carbon,water-saving and economic development scenarios,can save water of 998.48 × 104 m3,reduce carbon emission intensity by 4.27%,and make GDP rising rate up to 4.73%on the basis of benchmark year 2017.Water resources are used efficiently and carbon emission is largely reduced,while economy gains high-quality development.Chemical industrial structure needs to be adjusted through developing rubber and plastics,limiting petroleum processing,coking coal and nuclear fuel processing,using water-saving and carbon-reducing measures in chemical fiber manufacturing.Optimization of chemical industry needs to promote clean energy and reform energy consuming structure,with coal use down by 5.54%and gas & electricity use up by 5.45%.Water resources allocation should be consistent with industrial structural adjustment,which can save water by 9.8%in petroleum processing,coking coal and nuclear fuel processing,and 5.14%in chemical fiber manufacturing,which can be transferred to rubber and plastics sector.This paper presents suggestions on increasing regional ecological carrying capacity to realize high-quality development,establishing clean energy consuming system to raise energy efficiency,developing water-saving industries to materialize a coordinated sustainability in industrial development and water ecology.