Objective To analyze the epidemiological characteristics of hand-foot-mouth disease(HFMD)during 2012 to 2022 in Wanzhou District of Chongqing,so as to provide a scientific basis for the control prevention.Methods Descriptive epidemiological method,Chi-square test and t-test were used to analyze the reported case data of HFMD with current address in Wanzhou District from 2012 to 2022 obtained from the China Disease Prevention and Control Information System.ArcGIS 10.8 and SPSS 23.0 software were used for statistical analysis of the data,and the test level α was 0.05.Results A total of 24 379 HFMD cases were reported in Wanzhou District from 2012 to 2022,average annual incidence rate was 141.04 cases per 105,including 84 severe cases and 6 deaths.The average monthly incidence of HFMD from 2020 to 2022(during the COVID-19 pandemic)was significantly lower than that from 2012 to 2019(before the COVID-19 pandemic)(t=2.249,P=0.026).Before the COVID-19 epidemic,the incidence of HFMD showed a seasonal bimodal distribution,and with the characteristics of rising fluctuation and high incidence every other year.During the CO VID-19 pandemic,the seasonal bimodal feature of HFMD disappeared in 2020 and 2022.HFMD cases were concentrated in children younger than five years old(88.13％)and scattered children(62.43％).During the COVID-19 epidemic,the proportion of HFMD cases in the age group of three years and older increased by 7.03％compared with that before the COVID-19 epidemic,and the proportion of cases in childcare facilities'children and students increased by 6.26％.The top five areas with average annual reported incidence were all located in the central urban area.There were 744 cumulative laboratory diagnosed cases during 2012 to 2022,the number of cases infected with EV A71 decreased after reaching a peak in 2015(65.83％),and the proportion recovered in 2022(28.57％).Conclusions The incidence of HFMD decreased significantly during COVID-19 epidemic,and it should be noted that the incidence of HFMD rise again after the implementation of"class B tube"for COVID-19 infection.Education in Kindergartens and primary schools should be strengthened while focusing on preschool child vaccination and health advocacy education efforts.In order to prevent the increase of EV A71 infections,the EV 71 vaccination campaign should not be relaxed.
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