Objective To compare the retinal peripheral defocus(RDV)in adults with different degrees of myopia and to analyze the relationship between retinal peripheral defocus and shape parameters of the cornea.Methods 302 pa-tients with myopia were collected in this study.The data were divided into 3 groups according to spherical equivalent re-fraction(SE):low myopia(-3.00<SE≤-0.50D),moderate myopia(-6.00D<SE≤-3.00D),and high myopia(-9.00D<SE≤-6.00D).RDV and parameters such as corneal astigmatism(AST)and surface asymmetry index(SAI)were measured in each region,and RDV was compared between the groups and analyzed their correlation with each param-eter of the cornea shape.Results RDV beyond 20° of eccentricity showed hyperopia in all three groups and increased with increasing eccentricity(all P<0.05);RDV20°-53° were significantly different between the low and moderate myopia group and the low and high myopia group(all P<0.01);There was a significant difference between the moderate myopia group and the high myopia group for RDV20°-30°(P<0.05).TRDV positively correlated with AST(P<0.05);RDV10°-30° negatively correlated with SAI(all P<0.05).Conclusion Peripheral retinal defocus increases with increasing eccentricity in adults with varying degrees of myopia.To some extent,it is affected by the shape parameters of the cornea.