内毒素性实热证猕猴视网膜血管直径变化研究
Study of retinal vessel diameter changes in rhesus monkeys with endotoxin-inducedexcess heat syndrome
吴艳霞 1宋姗姗 2路雪婧3
作者信息
- 1. 610075,四川成都,成都中医药大学眼科学院;610084,四川成都,成都中医大银海眼科医院
- 2. 610075,四川成都,成都中医药大学国学院
- 3. 610075,四川成都,成都中医药大学眼科学院;610084,四川成都,成都中医大银海眼科医院;610075,四川成都,中医药眼病防治与视功能保护四川省重点实验室;610075,四川成都,视网膜图像技术与慢性血管性疾病防治协同创新中心
- 折叠
摘要
目的 探索内毒素性实热证猕猴视网膜血管直径的变化.方法 本研究采用内毒素肌肉注射建立猕猴实热证模型;造模成功后,利用Oxymap设备采集眼底图片,并对视网膜动、静脉直径进行分析;实热证组和对照组的直径大小变化数据分析采用独立样本t检验.结果 内毒素性实热证猕猴模型造模成功.实热证组与对照组相比静脉、鼻侧动脉直径明显缩小(P＜0.05);而颞上动脉和颞下动脉直径虽有不同程度缩小(P＞0.05).结论 内毒素性实热证猕猴的视网膜血管直径会呈现不同程度的收缩.视网膜血管直径具有成为中医证候定量指标的潜力.
Abstract
Objective To explore the changes of retinal vessel diameter of rhesus monkeys with endotoxin-induced excess heat syndrome.Methods In this study,we established an experimental pyrexia macaque model by intramuscularly injecting endotoxin.After successful modeling,Oxymap was used to capture fundus images of the macaques,and subse-quent analysis focused on assessing retinal artery and vein diameters.An independent samples t-test was employed to ana-lyze the variations in diameter between the experimental and control groups.Results The experimental group exhibited a significant decrease in the diameter of both venous and nasal arteries compared to the control group(P＜0.05).However,varying degrees of reduction were observed in the diameter of the superior temporal artery and inferior temporal artery(P＞0.05).Conclusion In the state of endotoxic fever,rhesus monkeys exhibit varying degrees of constriction in their reti-nal arteries and veins,suggesting the potential utility of retinal vessel diameter as a quantitative indicator for syndromes in traditional Chinese medicine.
关键词
中医证候模型/猕猴/视网膜血管直径/内毒素Key words
TCM syndrome model/Rhesus monkey/Retinal vessel diameter/Endotoxin引用本文复制引用
基金项目
国家重大科学仪器专项(2013YQ49085904)
成都中医药大学杏林学者学科人才研究推广计划(XKTD2022009)
中国中医科学院科技创新工程部传承与传播部项目(XJ2023001701)
出版年
2024
国家科技期刊平台
NSTL
万方数据