糖尿病视网膜病变(diabetic retinopathy,DR)是导致劳动年龄人群视力障碍的重要原因,其复杂的发病机制尚未完全明确.虽然一些新兴治疗方法在DR的治疗中取得显著疗效,但仍存在治疗效果欠佳及并发症等问题.Rho GTP酶是一种小分子蛋白,通过激活下游蛋白ROCK参与细胞骨架调节等多种细胞活动.在DR发病过程中Rho/ROCK信号通路被激活,抑制Rho/ROCK信号传导可能抑制DR的进展.本文从炎症、新生血管、血-视网膜屏障(blood retinal barrier,BRB)、晚期糖基化终末产物(advanced glycation end products,AGEs)、糖尿病视网膜神经变性(diabetic retinal neurodegeneration,DRN)等方面阐述Rho/ROCK信号通路在DR发病机制中的研究进展,以期为DR的治疗提供新思路.
Abstract
Diabetic retinopathy(DR)is an important cause of visual impairment in working-age people,and its com-plex pathogenesis has not been fully understood.Although some emerging treatment methods have achieved significant re-sults in the treatment of DR,there are still some problems with poor treatment effects and complications.RhoGTPase is a small molecule protein that participates in various cellular activities such as cytoskeleton regulation by activating the down-stream protein ROCK.During the pathogenesis of DR,the Rho/ROCK signaling pathway is activated,and inhibiting Rho/ROCK signaling may inhibit the progression of DR.This article explains the Rho/ROCK signal from the aspects of in-flammation、neovascularization、blood-retinal barrier(BRB)、advanced glycation end products(AGEs),and diabetic retinal neurodegeneration(DRN).The research progress of pathways in the pathogenesis of DR is expected to provide new ideas for the treatment of DR.
关键词
糖尿病视网膜病变/RhoGTP酶/ROCK/Rho/ROCK信号通路/ROCK抑制剂
Key words
Diabetic retinopathy/Rho GTP Ases/Rock/Rho/Rock Signal Pathway/Rock Inhibitor
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