基于层次分析-熵权法优选温肺平喘汤的提取工艺
Optimization of Extraction Process of Wenfei Pingchuan Decoction Based on Analytic Hierarchy Process and Entropy Weight Method
王博 1王瑞 1王佳 2吴作敏 1于晓涛1
作者信息
- 1. 漯河市中心医院 药学部,河南 漯河 462000;河南省中药制剂与加工中医药重点实验室,河南 漯河 462000
- 2. 漯河市中心医院 药学部,河南 漯河 462000
- 折叠
摘要
目的:采用层次分析(AHP)-熵权法(EWM)建立多指标综合评价复方的方法,优化温肺平喘汤的提取工艺.方法:以芍药苷、甘草苷、迷迭香酸、丹酚酸B、甘草酸含量和干浸膏得率为评价指标,采用AHP-EWM确定权重系数,通过L9(34)正交设计考察加水倍量、提取时间、提取次数对温肺平喘汤提取工艺的影响.结果:最佳提取工艺为 8 倍量水提取 3 次,每次 1 h.结论:优选的提取工艺重复性好、稳定性好、提取率高,适用于温肺平喘汤的标准化生产.
Abstract
Objective:The analytic hierarchy process(AHP)and entropy weight method(EWM)was used to establish a multi-index comprehensive evaluation method to optimize the extraction process of Wenfei Pingchuan Decoction.Methods:The content of paeoniflorin,liquiritin,rosmarinic acid,salvianolic acid B,glycyrrhizic acid and the yield of dry extract were used as evaluation indexes.The weight coefficient was determined by AHP and EWM.L9(34)orthogonal design was used to investigate the effects of water addition,extraction time and number of extractions on the extraction process of Wenfei Pingchuan Decoction.Results:The optimal extraction process was to extract 3 times with 8 times amount of waterfor 1 h each time.Conclusion:The optimized extraction condition has good repeatability,stability and high extraction rate,which is suitable for the standardized production of Wenfei Pingchuan Decoction.
关键词
温肺平喘汤/提取工艺/层次分析-熵权法/丹酚酸BKey words
Wenfei Pingchuan Decoction/extraction process/analytic hierarchy process and entropy weight method/salvianolic acid B引用本文复制引用
基金项目
中央引导地方科技发展专项(漯财预指[020]309号)
河南省中医药科研专项(2023ZY3033)
出版年
2024
国家科技期刊平台
NSTL
万方数据