摘要
经典名方升陷汤由黄芪、知母、柴胡、升麻和桔梗组成,主治大气下陷证,现代临床主要用于治疗循环和呼吸系统的疾病.对近年来升陷汤化学成分、药理作用和临床应用的研究进展进行整理归纳和分析,并从质量传递与溯源、成分可测性、成分有效性、成分特有性及复方配伍环境 5 个方面对升陷汤质量标志物(Q-marker)进行预测,分析发现黄芪甲苷、毛蕊异黄酮苷、毛蕊异黄酮、芒柄花苷、芒柄花素、柴胡皂苷A、柴胡皂苷D、芒果苷、知母皂苷B-Ⅱ、阿魏酸、异阿魏酸和桔梗皂苷D可作为升陷汤的Q-marker,为经典名方升陷汤质量控制体系和全过程质量溯源体系建立提供科学依据.
Abstract
Classical prescription Shengxian Decoction,composed of Radix Astragali,Rhizoma Anemarrhenae,Radix Bupleuri,Rhizoma Cimicifugae and Radix Platycodonis,is mainly used to treat the sinking of pectoral qi.Clinically,the prescription is widely used for the treatment of circulatory and respiratory system diseases.In this paper,the research progress on the chemical component,pharmacological action and clinical application of Shengxian Decoction in recent years was summarized and analyzed,and the quality markers(Q-markers)were predicted from five aspects:quality transfer and traceability,component measurability,component effectiveness,component specificity and compound compatibility.The result showed that astragaloside Ⅳ,calycosin-7-O-β-D-glucoside,caylcosin,ononin,formononetin,saikosaponin A,saikosaponin D,mangiferin,timosaponin B-Ⅱ,ferulic acid,isoferulic acid and platycodon D could be used as Q-markers for Shengxian Decoction,which provided scientific basis for the establishment of the quality control system and the whole-process quality traceability system of the prescription.
国家科技期刊平台
NSTL
维普
万方数据