Research Progress on Pharmacodynamics and Molecular Identification of Active Polypeptides from Animal-derived Chinese Medicine
Animal-derived medicines hold a significant position in traditional Chinese medicine,they have been widely practiced in China for thousands of years.The clinical application and pharmacological activity of these medicines have remained central topics of research.Among them,proteins and peptides derived from animals are identified as crucial molecular foundations for their pharmacological effects.Peptide drugs are poised to become a new focus in international pharmaceutical research,with animal-derived medicines attracting significant attention as a"treasure trove"due to their abundance of active peptides with potential therapeutic effects.This paper aims to systematically review existing literature,summarizing the recent advancements in the pharmacological functions of active peptides in animal-derived medicines.Additionally,common methods for peptide analysis,identification,and discovery are introduced,with a particular emphasis on the application strategies and current status of liquid chromatography-mass spectrometry(LC-MS)technology in studying peptide components of animal-derived medicines.Overall,LC-MS technology exhibits unique advantages in the research of peptide components in animal-derived medicines.This technology has significant impact in the identification of authenticity,quality control,and screening of potentially active peptides of animal-derived medicines,providing a reference for a in-depth understanding of the mechanisms of action of animal-derived medicines and the advancement of peptide-based drugs.
国家科技期刊平台
NSTL
万方数据
维普
