中国现代中药2024,Vol.26Issue(5) :848-855.DOI:10.13313/j.issn.1673-4890.20231201003

ICP-MS测定诃子炮制前后无机元素含量及安全性评价

Determination of Inorganic Element Content and Safety Evaluation of Terminalia chebula before and after Processing by ICP-MS

李华爽 姜媛媛 余少君 叶婉婷 马涛 陶欧 刘永刚
中国现代中药2024,Vol.26Issue(5) :848-855.DOI:10.13313/j.issn.1673-4890.20231201003

ICP-MS测定诃子炮制前后无机元素含量及安全性评价

Determination of Inorganic Element Content and Safety Evaluation of Terminalia chebula before and after Processing by ICP-MS

李华爽 1姜媛媛 2余少君 1叶婉婷 1马涛 1陶欧 1刘永刚1
扫码查看

作者信息

  • 1. 北京中医药大学,北京 100029
  • 2. 百济神州(北京)生物科技有限公司,北京 100022
  • 折叠

摘要

目的:建立诃子生品及清炒、麸煨、砂烫、烘制 4 种炮制品中 26 个无机元素的分析方法,对其中重金属及有害元素进行健康风险评估.方法:采用电感耦合等离子体质谱法,以铑和铼为内标,通过标准曲线法测定诃子中的 26 个元素;采用危害指数(HI)法和暴露限值(MOE)法进行健康风险评估.结果:26 个元素的标准曲线线性关系良好,仪器检出限为 0.000 2~0.434 2 μg·kg-1,加样回收率为 83.21%~116.84%.诃子炮制前后无机元素差异明显,部分重金属及有害元素所致健康风险较低.结论:该方法简便、准确,适用于诃子中无机元素的含量测定,为其重金属及有害元素健康风险评估提供了参考.

Abstract

Objective:A method was established to analyze 26 inorganic elements in raw products,stir-fried products without adjuvant,stir-fried products with bran,products scalded with sand,and baked products of Terminalia chebula.The health risk of heavy metals and harmful elements in T.chebula were assessed.Methods:By using inductively coupled plasma-mass spectrometry(ICP-MS),the 26 elements were determined by the standard curve method with rhodium and rhenium as internal standards;the hazard index(HI)method and the limit of exposure(MOE)method were used for health risk assessment.Results:The standard curves for the 26 elements exhibited excellent linear relationships,with instrumental detection limits varying from 0.000 2 to 0.434 2 μg·kg-1,and the spiked recoveries of 83.21%-116.84%.Notable distinctions in inorganic elements in T.chebula before and after processing were observed.Some heavy metals and harmful elements posed a low risk to human health.Conclusion:The method is accessible,precise,and well-suited for determining inorganic element content in T.chebula,providing a reference for health risk assessment of heavy metals and harmful elements.

关键词

诃子/电感耦合等离子体质谱法/炮制/无机元素/重金属及有害元素/风险评估

Key words

Terminalia chebula Retz./ICP-MS/processing/inorganic elements/heavy metals and harmful elements/risk assessment

引用本文复制引用

基金项目

国家自然科学基金重点项目(82130113)

出版年

2024
中国现代中药
中国中药协会,中国医药集团总公司,中国药材公司

中国现代中药

CSTPCD
影响因子:0.65
ISSN:1673-4890
参考文献量21
段落导航相关论文