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ICP-MS测定诃子炮制前后无机元素含量及安全性评价

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目的:建立诃子生品及清炒、麸煨、砂烫、烘制 4 种炮制品中 26 个无机元素的分析方法,对其中重金属及有害元素进行健康风险评估.方法:采用电感耦合等离子体质谱法,以铑和铼为内标,通过标准曲线法测定诃子中的 26 个元素;采用危害指数(HI)法和暴露限值(MOE)法进行健康风险评估.结果:26 个元素的标准曲线线性关系良好,仪器检出限为 0.000 2~0.434 2 μg·kg-1,加样回收率为 83.21%~116.84%.诃子炮制前后无机元素差异明显,部分重金属及有害元素所致健康风险较低.结论:该方法简便、准确,适用于诃子中无机元素的含量测定,为其重金属及有害元素健康风险评估提供了参考.
Determination of Inorganic Element Content and Safety Evaluation of Terminalia chebula before and after Processing by ICP-MS
Objective:A method was established to analyze 26 inorganic elements in raw products,stir-fried products without adjuvant,stir-fried products with bran,products scalded with sand,and baked products of Terminalia chebula.The health risk of heavy metals and harmful elements in T.chebula were assessed.Methods:By using inductively coupled plasma-mass spectrometry(ICP-MS),the 26 elements were determined by the standard curve method with rhodium and rhenium as internal standards;the hazard index(HI)method and the limit of exposure(MOE)method were used for health risk assessment.Results:The standard curves for the 26 elements exhibited excellent linear relationships,with instrumental detection limits varying from 0.000 2 to 0.434 2 μg·kg-1,and the spiked recoveries of 83.21%-116.84%.Notable distinctions in inorganic elements in T.chebula before and after processing were observed.Some heavy metals and harmful elements posed a low risk to human health.Conclusion:The method is accessible,precise,and well-suited for determining inorganic element content in T.chebula,providing a reference for health risk assessment of heavy metals and harmful elements.

Terminalia chebula Retz.ICP-MSprocessinginorganic elementsheavy metals and harmful elementsrisk assessment

李华爽、姜媛媛、余少君、叶婉婷、马涛、陶欧、刘永刚

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北京中医药大学,北京 100029

百济神州(北京)生物科技有限公司,北京 100022

诃子 电感耦合等离子体质谱法 炮制 无机元素 重金属及有害元素 风险评估

国家自然科学基金重点项目

82130113

2024

中国现代中药
中国中药协会,中国医药集团总公司,中国药材公司

中国现代中药

CSTPCD
影响因子:0.65
ISSN:1673-4890
年,卷(期):2024.26(5)
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