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虎杖研究进展及质量标志物预测

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虎杖是我国常用的大宗中药材,资源丰富且分布较广,具有广阔的开发利用前景.虎杖中化学成分类型丰富,包括二苯乙烯、醌、黄酮等类化合物,虎杖的药理作用主要体现在抗炎、抗氧化、抗病毒、抗菌、抗癌、肝保护、心血管保护、免疫调节等方面.在对其化学成分、药理作用综述的基础上,根据中药质量标志物(Q-marker)理论,从生源途径、化学成分有效性、化学成分可测性及不同配伍环境几方面对虎杖Q-marker进行预测分析,为明确虎杖的Q-marker和制定科学的质量标准提供参考.
Research Progress and Q-marker Prediction Analysis of Traditional Chinese Medicine Polygonum cuspidatum
Polygonum cuspidatum(P.cuspidatum)is a commonly used bulk traditional Chinese medicine(TCM)in China,with rich resources and wide distribution,and has broad prospects for development and utilization.P.cuspidatum has a wide range of chemical components,including stilbenes,anthraquinones,flavonoids and other compounds.The pharmacological effects of P.cuspidatum are mainly anti-inflammatory,antioxidant,antiviral,antibacterial,anticancer effects,liver protection,cardiovascular protection,immune regulation and so on.Based on the summary of its chemical components and pharmacological effects,and the theory of quality marker(Q-marker)of TCM,the Q-marker components of P.cuspidatum were predicted and analyzed from the aspects of the source of TCM,chemical component effectiveness,chemical component detectability and different compatibility environments,so as to provide a basis for clarifying the Q-marker of P.cuspidatum and formulating scientific quality standards.

Polygonum cuspidatum Sieb.et Zucc.Q-markersanthraquinonesstilbenesquality control

侯淇允、张林林、郝艳琦、许浚、张铁军

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天津中医药大学,天津 301617

天津药物研究院 药物成药性评价与系统转化全国重点实验室,天津 300462

天津药物研究院 天津市中药质量标志物重点实验室,天津 300462

和光中药科技(天津)有限公司,天津 300301

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虎杖 质量标志物 蒽醌类 二苯乙烯类 质量控制

安徽省科技重大专项

202303a07020007

2024

中国现代中药
中国中药协会,中国医药集团总公司,中国药材公司

中国现代中药

CSTPCD
影响因子:0.65
ISSN:1673-4890
年,卷(期):2024.26(5)
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