Comparison of Volatile Oil Components in Roots of Five Bupleurum Species Based on GC-MS and Network Pharmacology
Objective:To compare the volatile oil components and potential pharmacological activities of dried roots of Bupleurum chinense DC.,B.scorzonerifolium Willd.,B.marginatum var.stenophyllum(Wolff)Shan et Y.Li,B.marginatum Wall.ex DC.,and B.smithii Wolff based on gas chromatography-mass spectrometry(GC-MS)and network pharmacology.Methods:The volatile oils from the roots of these five Bupleurum species were extracted by steam distillation.GC-MS was employed for qualitative analysis of the volatile oil components.A component-target network was constructed,and enrichment analysis was performed using the Kyoto Encyclopedia of Genes and Genomes(KEGG).Results:There were differences in the composition of volatile oil compounds among the five Bupleurum species,with a total of 55 compounds identified.Network pharmacology analysis indicated that the volatile oils of these five Bupleurum species shared similar target proteins,such as NFKB1,PIK3R1,PIK3CD,and NOS2.These core targets were involved in pathways including neuroactive ligand-receptor interaction,neutrophil extracellular trap formation,sphingolipid signaling pathway,and small cell lung cancer signaling pathways.Conclusion:The volatile oils of these five Bupleurum species potentially exhibit mutual substitution effects in anti-infection,anti-inflammatory,neuroprotective,and anti-tumor activities.
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