UPLC-MS/MS联合m-PFC测定罗汉果中60种农药残留量

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中文摘要：目的:建立罗汉果中 60 种农药残留的定量筛查方法.方法:样品经乙腈高速匀浆提取、多壁碳纳米管固相萃取小柱净化,采用超高效液相色谱-质谱法,以正、负离子同时扫描的动态多反应监测模式采集数据,采用空白基质匹配法进行定量计算.结果:60 种农药线性关系良好,r均大于 0.996.其中,59 种农药单体的平均回收率为 63.9%～108.3%,RSD均小于 15%.55 批样品中共检出 2 种禁用农药和 12 种常用农药.结论:该方法灵敏度高、准确性好,适用于罗汉果中多种农药残留的筛查.

外文标题：Determination of 60 Pesticide Residues in Siraitia grosvenoriis by m-PFC and UPLC-MS/MS

外文摘要：Objective:To establish a quantitative screening method for 60 pesticide residues in Siraitia grosvenoriis.Methods:The samples were extracted with acetonitrile by high-speed homogenizer and purified by multi-walled carbon nanotube solid-phase extraction.The data were collected by ultra-high performance liquid chromatography-mass spectrometry in a dynamic multi-reaction monitoring mode with simultaneous scanning of positive and negative ions.The blank matrix matching method was used for quantitative calculation.Results:The 60 pesticide residues show good linearity,with correlation coefficients r of above 0.996.The average recoveries of 59 pesticide residues range from 63.9%to 108.3%,with RSDs of less than 15%.Two forbidden pesticides and 12 common pesticides are found in 55 batches of samples.Conclusion:The method has good sensitivity and accuracy,suitable for the determination of multiple pesticide residues in Siraitia grosvenoriis.

外文关键词：

Siraitia grosvenorii(Swingle)C.Jeffrey ex A.M.Lu et Z.Y.Zhangmulti-walled carbon nanotubepesticide residuesultra-high performance liquid chromatography-mass spectrometry

作者：

李纯、黄志星、栗建明、顾利红

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作者单位：

国家药品监督管理局中成药质量评价重点实验室/广州市药品检验所,广东广州 510160

关键词：

罗汉果多壁碳纳米管农药残留超高效液相色谱-质谱法

基金：

国家药典委员会项目国家药典委员会项目国家药品监督管理局开放性课题

项目编号：

2024Z022022Z08NIFDC-TCM2023-0205-002

出版年：

2024

DOI：

10.13313/j.issn.1673-4890.20240112003

中国现代中药

中国中药协会,中国医药集团总公司,中国药材公司

中国现代中药

CSTPCD

影响因子：0.65

ISSN：1673-4890

年,卷(期)：2024.26(8)