摘要
痔病是以肛门黏膜静脉丛发生曲张为主要特征的慢性疾病,随着病程延长会伴有肿胀疼痛、黏液流出等病理表现,临床上表现为患处瘙痒、作痛、便血等.手术是治疗痔疮的有效方法之一,能够缓解病人痛苦,根治性较高.但手术费用昂贵,术后容易出现出血、肛门狭窄等不适.中药可通过多靶点、多途径发挥治疗痔病的作用,其作用机制主要是调控机体内外炎症反应、减轻脂质过氧化反应、抑制基质金属蛋白酶表达、调控血管生成和上调纤维蛋白的表达等.目前,对痔病的机制研究正逐渐深化,但尚未系统性阐述痔病发病及中药改善的作用机制,综述相关研究对防治痔病具有十分重要的意义.
Abstract
Hemorrhoids are a chronic disease mainly characterized by varicosity of the anal mucosal venous plexus.With the prolongation of the disease course,the patients with hemorrhoids will suffer from hematochezia,swelling pain,mucus discharge and other pathological changes.The clinical manifestations include pruritus,pain,and hematochezia.Surgery,one of the effective ways to treat hemorrhoids,can relieve the patient's pain and exert the curative effect.However,the operation is expensive,and the patients are prone to postoperative bleeding,anal stenosis,and other discomfort.Traditional Chinese medicine plays a role in the treatment of hemorrhoids via multiple targets and multiple ways,in which the mechanisms include regulating internal and external inflammation,reducing lipid peroxidation,inhibiting the expression of matrix metalloproteinases,modulating angiogenesis,and up-regulating the expression of fibulin.At present,the research on the mechanism of hemorrhoids is deepening,while the pathogenesis of this disease and the intervention mechanism of traditional Chinese medicine have not been systematically expounded.The review of relevant research is of great significance for the prevention and treatment of hemorrhoids.
维普
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