Antitumor Activity and Mechanism of Saposhnikovia divaricata Polysaccharide SP-3
Objective:To study the antitumor activity and mechanism of Saposhnikovia divaricata polysaccharide SP-3.Methods:The effects of SP-3 on cancer cell proliferation,cell cycle,and apoptosis were detected using the MTT assay and flow cytometry.The antitumor activity mechanism of SP-3 was studied using the Caenorhabditis elegans model.Results:SP-3 significantly inhibited the proliferation of gastric cancer AGS cells and hepatoma HepG2 cells,promoted apoptosis in gastric cancer AGS cells,and affected their cell cycle in a dose-dependent manner.Additionally,SP-3 exhibited a notable inhibitory effect on the multivulva phenotype in Ras gene mutant C.elegans.Conclusion:SP-3 has a potent antitumor effect,and its mechanism may be related to the Ras/mitogen-activated protein kinase(MAPK)pathway.
Saposhnikovia divaricata polysaccharide SP-3gastric cancer AGS cellsCaenorhabditis elegansRas/MAPK
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