中国现代中药2024,Vol.26Issue(9) :1586-1595.DOI:10.13313/j.issn.1673-4890.20240227007

基于电子舌、GC-IMS技术和人工感官评价对小儿感冒颗粒的气味分析及口感改善研究

Odor Analysis and Taste Improvement of Xiao'er Ganmao Granules Based on Electronic Tongue,GC-IMS Technology,and Artificial Sensory Evaluation

万顺 谭润泽 何倜 何金芳 郭静 白璐 龚云 张鹏 杨秀伟 凌勇根 王炜
中国现代中药2024,Vol.26Issue(9) :1586-1595.DOI:10.13313/j.issn.1673-4890.20240227007

基于电子舌、GC-IMS技术和人工感官评价对小儿感冒颗粒的气味分析及口感改善研究

Odor Analysis and Taste Improvement of Xiao'er Ganmao Granules Based on Electronic Tongue,GC-IMS Technology,and Artificial Sensory Evaluation

万顺 1谭润泽 2何倜 2何金芳 2郭静 2白璐 2龚云 2张鹏 2杨秀伟 3凌勇根 2王炜1
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作者信息

  • 1. 湖南中医药大学,湖南 长沙 410208
  • 2. 株洲千金药业股份有限公司,湖南 株洲 412007
  • 3. 北京大学 药学院 天然药物及仿生药物全国重点实验室,北京 100191
  • 折叠

摘要

目的:改善小儿感冒颗粒的口感,提高患者用药依从性.方法:采用气相色谱-离子迁移谱法(GC-IMS)分析小儿感冒颗粒气味并确定气味来源,采用电子舌分析评价热浸温度、加水量、矫味剂、贮存期等参数对小儿感冒颗粒口感的影响,并结合排序+评分法(ISEM)综合评价矫味剂对小儿感冒颗粒的矫味效果.结果:通过GC-IMS分析在小儿感冒颗粒中共检测出 57 个挥发性物质,气味主要来自挥发油、挥发油滤液和热浸液中的有机酸类及部分醛类;电子舌分析结果表明,生产工艺中不同参数各中间产品口感上的差别并不影响颗粒的最终口感,结合ISEM评价体系进行人工感官评价,最终得出添加 2‰氯化钠矫味可以明显改善小儿感冒颗粒的口感,其口感会随贮存期发生变化.结论:通过GC-IMS分析、电子舌智能感官评定与人工口尝评价相结合的方法可以科学合理地筛选出小儿感冒颗粒的最佳矫味剂组合,显著地改善其口感,优化制剂配方.

Abstract

Objective:To improve the taste of Xiao'er Ganmao Granules and improve the medication compliance of patients.Methods:In this experiment,the gas chromatography-ion mobility spectroscopy(GC-IMS)technology was used to analyze the odor of Xiao'er Ganmao Granules and to determine its source,and electronic tongue was used to evaluate the influence of production process parameters such as hot dipping temperature,water addition,flavoring agent,and storage period on the taste of Xiao'er Ganmao Granules.Moreover,the integrated score evaluation method(ISEM)was used to comprehensively evaluate the effect of the flavoring agent on Xiao'er Ganmao Granules.Results:From a total of 57 volatile substances detected in Xiao'er Ganmao Granules through GC-IMS analysis,The odor mainly came from the organic acids and some aldehydes in the volatile oil,volatile oil filtrate,and hot dipping solution.From the analysis of the electronic tongue,the difference in the taste of intermediate products under different parameters shows no effect on the final Granules.Using artificial sensory evaluation combined with ISEM,this study found that the addition of 2‰ sodium chloride can significantly improve the taste of Xiao'er Ganmao Granules,and it will change with the storage period.Conclusion:This study provides great references for improving the taste of Xiao'er Ganmao Granules by giving the above result.

关键词

电子舌/小儿感冒颗粒/口感/气味

Key words

electronic tongue/Xiao'er Ganmao Granules/taste/odor

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出版年

2024
中国现代中药
中国中药协会,中国医药集团总公司,中国药材公司

中国现代中药

CSTPCD
影响因子:0.65
ISSN:1673-4890
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