首页|龙骨炮制方法变迁及质量控制研究进展

龙骨炮制方法变迁及质量控制研究进展

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龙骨为我国中医临床常用的化石类矿物药,具有镇心安神、平肝潜阳、固涩、收敛的功效.以朝代-古籍-炮制方法为节点,以各节点度值进行拓扑分析并排列,构建龙骨炮制方法沿革网络,东晋至清代不同历史时期龙骨的炮制方法有所差异,主要有捣碎、研末、水飞、炒、烧、煅、淬、浸、煮、蒸等,所用的辅料有酒、醋、盐、黑豆、童便等.记载龙骨炮制方法的古代本草集中于宋代、明代、清代;类似现代明煅法的烧、煅法记载较多,为古代龙骨炮制的主流方法,以醋、酒、盐、酥油、黑豆、童便等为辅料的炮制方法逐渐被淘汰.龙骨的质量控制标准主要包括性状鉴别和理化鉴别,部分地方标准中有钙含量测定和有害物质、杂质、水分的限量要求.目前,龙骨的研究多集中于含有龙骨的复方或方剂的整体研究,在炮制方法、质量控制与分析、安全性、资源可持续利用等方面的研究较少.对龙骨的炮制方法、质量控制与分析技术进行综述,分析龙骨临床应用存在的问题,提出后期研究展望,以期为龙骨的质量控制与可持续利用提供参考.
Research Progress in Processing Methods and Quality Control of Draconis Os
Draconis Os is a commonly used mineral Chinese medicine,known for its effects of tranquilizing mind,pacifying liver and subduing yang,astringing,and consolidating.With dynasty-ancient medical book-processing method as nodes,a topological analysis was conducted with the nodes ranked based on the degree to build a network that delineated the historical evolution of the processing methods for Draconis Os.The processing methods of Draconis Os varied across different historical periods from the Eastern Jin dynasty to the Qing dynasty.The main methods included crushing,grinding,grinding in water,stir-frying,burning,calcining,quenching,soaking,boiling,and steaming,with auxiliary materials such as wine,vinegar,salt,black beans,and children's urine.The ancient medical books recording the processing methods of Draconis Os were mainly written in the Song,Ming,and Qing dynasties.The methods of burning and calcining,similar to calcinating in the air,had the most records and were the main methods of Draconis Os processing in ancient times.The processing methods with vinegar,wine,salt,butter,black beans,and children's urine were gradually phased out.The quality control standards for Draconis Os mainly include morphological identification and physicochemical identification,and some local standards included the determination of calcium content and the requirements for the limits of harmful substances,impurities,and moisture.The available studies on Draconis Os mostly focused on the overall study of formulas or prescriptions containing Draconis Os,and few researchers concerned the processing methods,quality control and analysis,safety,and sustainable utilization of resources.This article reviews the processing methods,quality control,and analytical techniques of Draconis Os,analyzes the existing problems in the clinical application of Draconis Os,and finally proposes suggestions for future research,aiming to provide a reference for the quality control,in-depth research,and sustainable utilization of Draconis Os.

mineral Chinese medicineDraconis Osprocessingqualityresource utilization

潘艳琼、刘政、马瑜璐、房方、钱喜龙、周柳、张颖、郑丽文、刘圣金

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中药制药过程控制与智能制造技术全国重点实验室,江苏 南京 210000

南京中医药大学 药学院,江苏 南京 210023

泰康仙林鼓楼医院,江苏 南京 210023

江苏省中药资源产业化过程协同创新中心,江苏 南京 210023

南京市中西医结合医院,江苏 南京 210014

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矿物药 龙骨 炮制 质量 资源利用

2024

中国现代中药
中国中药协会,中国医药集团总公司,中国药材公司

中国现代中药

CSTPCD
影响因子:0.65
ISSN:1673-4890
年,卷(期):2024.26(12)